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165 results
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Thrombin signalling and protease-activated receptors.
Coughlin SR. Coughlin SR. Nature. 2000 Sep 14;407(6801):258-64. doi: 10.1038/35025229. Nature. 2000. PMID: 11001069 Review.
Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.
Hung DT, Vu TH, Nelken NA, Coughlin SR. Hung DT, et al. Among authors: coughlin sr. J Cell Biol. 1992 Feb;116(3):827-32. doi: 10.1083/jcb.116.3.827. J Cell Biol. 1992. PMID: 1309820 Free PMC article.
Characterization of a functional thrombin receptor. Issues and opportunities.
Coughlin SR, Vu TK, Hung DT, Wheaton VI. Coughlin SR, et al. J Clin Invest. 1992 Feb;89(2):351-5. doi: 10.1172/JCI115592. J Clin Invest. 1992. PMID: 1310691 Free PMC article. Review. No abstract available.
"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.
Hung DT, Vu TK, Wheaton VI, Charo IF, Nelken NA, Esmon N, Esmon CT, Coughlin SR. Hung DT, et al. Among authors: coughlin sr. J Clin Invest. 1992 Feb;89(2):444-50. doi: 10.1172/JCI115604. J Clin Invest. 1992. PMID: 1310695 Free PMC article.
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.
Hung DT, Vu TK, Wheaton VI, Ishii K, Coughlin SR. Hung DT, et al. Among authors: coughlin sr. J Clin Invest. 1992 Apr;89(4):1350-3. doi: 10.1172/JCI115721. J Clin Invest. 1992. PMID: 1313452 Free PMC article.
Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function.
Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, Coughlin SR. Scarborough RM, et al. Among authors: coughlin sr. J Biol Chem. 1992 Jul 5;267(19):13146-9. J Biol Chem. 1992. PMID: 1320011
Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
Coughlin SR, Vu TK, Hung DT, Wheaton VI. Coughlin SR, et al. Semin Thromb Hemost. 1992;18(2):161-6. doi: 10.1055/s-2007-1002422. Semin Thromb Hemost. 1992. PMID: 1321504 No abstract available.
The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.
Hung DT, Wong YH, Vu TK, Coughlin SR. Hung DT, et al. Among authors: coughlin sr. J Biol Chem. 1992 Oct 15;267(29):20831-4. J Biol Chem. 1992. PMID: 1328213
Thrombin receptor expression in normal and atherosclerotic human arteries.
Nelken NA, Soifer SJ, O'Keefe J, Vu TK, Charo IF, Coughlin SR. Nelken NA, et al. Among authors: coughlin sr. J Clin Invest. 1992 Oct;90(4):1614-21. doi: 10.1172/JCI116031. J Clin Invest. 1992. PMID: 1328304 Free PMC article.
Thrombin receptor structure and function.
Coughlin SR, Scarborough RM, Vu TK, Hung DT. Coughlin SR, et al. Cold Spring Harb Symp Quant Biol. 1992;57:149-54. doi: 10.1101/sqb.1992.057.01.019. Cold Spring Harb Symp Quant Biol. 1992. PMID: 1339654 Review. No abstract available.
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