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Recent developments in adeno-associated virus vector technology.
Büning H, Perabo L, Coutelle O, Quadt-Humme S, Hallek M. Büning H, et al. Among authors: coutelle o. J Gene Med. 2008 Jul;10(7):717-33. doi: 10.1002/jgm.1205. J Gene Med. 2008. PMID: 18452237 Review.
Successful target cell transduction of capsid-engineered rAAV vectors requires clathrin-dependent endocytosis.
Uhrig S, Coutelle O, Wiehe T, Perabo L, Hallek M, Büning H. Uhrig S, et al. Among authors: coutelle o. Gene Ther. 2012 Feb;19(2):210-8. doi: 10.1038/gt.2011.78. Epub 2011 Jun 9. Gene Ther. 2012. PMID: 21654820
Combined paracrine and endocrine AAV9 mediated expression of hepatocyte growth factor for the treatment of renal fibrosis.
Schievenbusch S, Strack I, Scheffler M, Nischt R, Coutelle O, Hösel M, Hallek M, Fries JW, Dienes HP, Odenthal M, Büning H. Schievenbusch S, et al. Among authors: coutelle o. Mol Ther. 2010 Jul;18(7):1302-9. doi: 10.1038/mt.2010.71. Epub 2010 Apr 27. Mol Ther. 2010. PMID: 20424598 Free PMC article.
Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles.
Stahnke S, Lux K, Uhrig S, Kreppel F, Hösel M, Coutelle O, Ogris M, Hallek M, Büning H. Stahnke S, et al. Among authors: coutelle o. Virology. 2011 Jan 5;409(1):77-83. doi: 10.1016/j.virol.2010.09.025. Epub 2010 Oct 25. Virology. 2011. PMID: 20974479
The neural cell adhesion molecule L1: genomic organisation and differential splicing is conserved between man and the pufferfish Fugu.
Coutelle O, Nyakatura G, Taudien S, Elgar G, Brenner S, Platzer M, Drescher B, Jouet M, Kenwrick S, Rosenthal A. Coutelle O, et al. Gene. 1998 Feb 16;208(1):7-15. doi: 10.1016/s0378-1119(97)00614-8. Gene. 1998. PMID: 9479034
Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.
Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H. Coutelle O, et al. EMBO Mol Med. 2014 May;6(5):624-39. doi: 10.1002/emmm.201303016. EMBO Mol Med. 2014. PMID: 24648500 Free PMC article.
Elevated XIAP expression alone does not confer chemoresistance.
Seeger JM, Brinkmann K, Yazdanpanah B, Haubert D, Pongratz C, Coutelle O, Krönke M, Kashkar H. Seeger JM, et al. Among authors: coutelle o. Br J Cancer. 2010 Jun 8;102(12):1717-23. doi: 10.1038/sj.bjc.6605704. Epub 2010 May 18. Br J Cancer. 2010. PMID: 20485285 Free PMC article.
BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.
Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H. Andree M, et al. Among authors: coutelle o. EMBO J. 2014 Oct 1;33(19):2171-87. doi: 10.15252/embj.201387244. Epub 2014 Jul 23. EMBO J. 2014. PMID: 25056906 Free PMC article.
Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction.
Kwiecinski M, Noetel A, Elfimova N, Trebicka J, Schievenbusch S, Strack I, Molnar L, von Brandenstein M, Töx U, Nischt R, Coutelle O, Dienes HP, Odenthal M. Kwiecinski M, et al. Among authors: coutelle o. PLoS One. 2011;6(9):e24568. doi: 10.1371/journal.pone.0024568. Epub 2011 Sep 9. PLoS One. 2011. PMID: 21931759 Free PMC article.
A combination of low-dose bevacizumab and imatinib enhances vascular normalisation without inducing extracellular matrix deposition.
Schiffmann LM, Brunold M, Liwschitz M, Goede V, Loges S, Wroblewski M, Quaas A, Alakus H, Stippel D, Bruns CJ, Hallek M, Kashkar H, Hacker UT, Coutelle O. Schiffmann LM, et al. Among authors: coutelle o. Br J Cancer. 2017 Feb 28;116(5):600-608. doi: 10.1038/bjc.2017.13. Epub 2017 Jan 31. Br J Cancer. 2017. PMID: 28141797 Free PMC article.
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