Cowan K - Search Results

1

The assay design used for measurement of therapeutic antibody concentrations can affect pharmacokinetic parameters: Case studies.

Fischer SK, Yang J, Anand B, Cowan K, Hendricks R, Li J, Nakamura G, Song A. Fischer SK, et al. Among authors: cowan k. MAbs. 2012 Sep-Oct;4(5):623-31. doi: 10.4161/mabs.20814. Epub 2012 Jul 23. MAbs. 2012. PMID: 22820463 Free PMC article.

2

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

Zheng Y, Tesar DB, Benincosa L, Birnböck H, Boswell CA, Bumbaca D, Cowan KJ, Danilenko DM, Daugherty AL, Fielder PJ, Grimm HP, Joshi A, Justies N, Kolaitis G, Lewin-Koh N, Li J, McVay S, O'Mahony J, Otteneder M, Pantze M, Putnam WS, Qiu ZJ, Ruppel J, Singer T, Stauch O, Theil FP, Visich J, Yang J, Ying Y, Khawli LA, Richter WF. Zheng Y, et al. MAbs. 2012 Mar-Apr;4(2):243-55. doi: 10.4161/mabs.4.2.19387. Epub 2012 Mar 1. MAbs. 2012. PMID: 22453096 Free PMC article.

3

Utilizing design of experiments to characterize assay robustness.

Cowan KJ, Erickson R, Sue B, Delarosa R, Gunter B, Coleman DA, Gilbert H, Song A, Fischer SK. Cowan KJ, et al. Bioanalysis. 2012 Sep;4(17):2127-39. doi: 10.4155/bio.12.199. Bioanalysis. 2012. PMID: 23013395

4

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys.

Leabman MK, Meng YG, Kelley RF, DeForge LE, Cowan KJ, Iyer S. Leabman MK, et al. Among authors: cowan kj. MAbs. 2013 Nov-Dec;5(6):896-903. doi: 10.4161/mabs.26436. MAbs. 2013. PMID: 24492343 Free PMC article.

5

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor.

Deng R, Bumbaca D, Pastuskovas CV, Boswell CA, West D, Cowan KJ, Chiu H, McBride J, Johnson C, Xin Y, Koeppen H, Leabman M, Iyer S. Deng R, et al. MAbs. 2016;8(3):593-603. doi: 10.1080/19420862.2015.1136043. Epub 2016 Feb 26. MAbs. 2016. PMID: 26918260 Free PMC article.

6

Impact of SPR biosensor assay configuration on antibody: Neonatal Fc receptor binding data.

Wang X, McKay P, Yee LT, Dutina G, Hass PE, Nijem I, Allison D, Cowan KJ, Lin K, Quarmby V, Yang J. Wang X, et al. Among authors: cowan kj. MAbs. 2017 Feb/Mar;9(2):319-332. doi: 10.1080/19420862.2016.1261774. Epub 2016 Dec 21. MAbs. 2017. PMID: 28001487 Free PMC article.

7

Preclinical pharmacokinetic characterization of an adipose tissue-targeting monoclonal antibody in obese and non-obese animals.

Rajan S, Mandikian D, Baruch A, Gelzleichter TR, Stevens D, Sonoda J, Cowan K, Boswell CA, Stefanich E. Rajan S, et al. Among authors: cowan k. MAbs. 2017 Nov/Dec;9(8):1379-1388. doi: 10.1080/19420862.2017.1373923. Epub 2017 Sep 12. MAbs. 2017. PMID: 28895785 Free PMC article.

8

Pharmacokinetics and biodistribution of a human monoclonal antibody to oxidized LDL in cynomolgus monkey using PET imaging.

Kamath AV, Williams SP, Bullens S, Cowan KJ, Stenberg Y, Cherry SR, Rendig S, Kukis DL, Griesemer C, Damico-Beyer LA, Bunting S. Kamath AV, et al. PLoS One. 2012;7(9):e45116. doi: 10.1371/journal.pone.0045116. Epub 2012 Sep 17. PLoS One. 2012. PMID: 23028793 Free PMC article.

9

A phase 1 study to evaluate the safety and LDL cholesterol-lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9.

Baruch A, Luca D, Kahn RS, Cowan KJ, Leabman M, Budha NR, Chiu CPC, Wu Y, Kirchhofer D, Peterson A, Davis JC Jr, Tingley WG. Baruch A, et al. Clin Cardiol. 2017 Jul;40(7):503-511. doi: 10.1002/clc.22687. Epub 2017 Mar 22. Clin Cardiol. 2017. PMID: 28326559 Free PMC article. Clinical Trial.

10

Anti-drug Antibody Sample Testing and Reporting Harmonization.

Jani D, Marsden R, Gunsior M, Hay LS, Ward B, Cowan KJ, Azadeh M, Barker B, Cao L, Closson KR, Coble K, Dholakiya SL, Dusseault J, Hays A, Herl C, Hodsdon ME, Irvin SC, Kirshner S, Kolaitis G, Kulagina N, Kumar S, Lai CH, Lipari F, Liu S, Merdek KD, Moldovan IR, Mozaffari R, Pan L, Place C, Snoeck V, Manning MS, Stocker D, Tary-Lehmann M, Turner A, Vainshtein I, Verthelyi D, Williams WT, Yan H, Yan W, Yang L, Yang L, Zemo J, Zhong ZD. Jani D, et al. Among authors: cowan kj. AAPS J. 2022 Oct 28;24(6):113. doi: 10.1208/s12248-022-00762-6. AAPS J. 2022. PMID: 36307592

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