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Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB.
Otterson GA, Kratzke RA, Coxon A, Kim YW, Kaye FJ. Otterson GA, et al. Oncogene. 1994 Nov;9(11):3375-8. Oncogene. 1994. PMID: 7936665
The identification of a cdk4 inhibitor, p16INK4, as a target for mutations in cultured tumor lines and primary tumors suggested that RB activity may be affected in these cells. ...The inverse correlation of RB and p16INK4 expression and the absence of p16INK4 inacti …
The identification of a cdk4 inhibitor, p16INK4, as a target for mutations in cultured tumor lines and primary tumors suggeste …
Assessment of cancer cell line representativeness using microarrays for Merkel cell carcinoma.
Daily K, Coxon A, Williams JS, Lee CR, Coit DG, Busam KJ, Brownell I. Daily K, et al. J Invest Dermatol. 2015 Apr;135(4):1138-1146. doi: 10.1038/jid.2014.518. Epub 2014 Dec 18. J Invest Dermatol. 2015. PMID: 25521454 Free PMC article.
Using whole transcriptome gene expression signatures and a computational bioinformatic approach, we identified significant differences between variant cell lines (UISO, MCC13, and MCC26) and fresh frozen MCC tumors. ...
Using whole transcriptome gene expression signatures and a computational bioinformatic approach, we identified significant difference …
Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes.
Coxon A, Rozenblum E, Park YS, Joshi N, Tsurutani J, Dennis PA, Kirsch IR, Kaye FJ. Coxon A, et al. Cancer Res. 2005 Aug 15;65(16):7137-44. doi: 10.1158/0008-5472.CAN-05-1125. Cancer Res. 2005. PMID: 16103063
Malignant salivary gland tumors can arise from a t(11;19) translocation that fuses 42 residues from Mect1/Torc1, a cyclic AMP (cAMP)/cAMP-responsive element binding protein (CREB)-dependent transcriptional coactivator, with 982 residues from Maml2, a NOTCH re …
Malignant salivary gland tumors can arise from a t(11;19) translocation that fuses 42 residues from Mect1/Torc1, a cyclic AMP …
Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras.
Park Y, Kubo A, Komiya T, Coxon A, Beebe K, Neckers L, Meltzer PS, Kaye FJ. Park Y, et al. Cell Cycle. 2008 Aug;7(15):2384-91. doi: 10.4161/cc.6363. Epub 2008 May 30. Cell Cycle. 2008. PMID: 18677112 Free PMC article.
In addition, we studied a small-cell carcinoma that is homozygous for the R661W allele providing the first analysis of the effect of a naturally occurring lp allele in a human tumor. ...These findings show that a recurrent missense lp allele retains gr …
In addition, we studied a small-cell carcinoma that is homozygous for the R661W allele providing the first analysis of the effect of …
t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.
Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ. Tonon G, et al. Nat Genet. 2003 Feb;33(2):208-13. doi: 10.1038/ng1083. Epub 2003 Jan 21. Nat Genet. 2003. PMID: 12539049
Here we identify a new mechanism for disrupting Notch signaling in human tumorigenesis, characterized by altered function of a new ortholog of the Drosophila melanogaster Notch co-activator molecule Mastermind. ...MECT1-MAML2 induced foci formation in RK3E epithelia …
Here we identify a new mechanism for disrupting Notch signaling in human tumorigenesis, characterized by altered function of a
Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation.
Komiya T, Park Y, Modi S, Coxon AB, Oh H, Kaye FJ. Komiya T, et al. Oncogene. 2006 Oct 5;25(45):6128-32. doi: 10.1038/sj.onc.1209627. Epub 2006 May 1. Oncogene. 2006. PMID: 16652146
Mucoepidermoid (MEC) salivary gland tumors arise from a t(11;19) rearrangement which generates a fusion oncogene, Mect1-Maml2, that functions to activate CREB-responsive target genes. ...Our data show that the 'gain-of-function' activity from aberrant Mect1-Maml2 ex …
Mucoepidermoid (MEC) salivary gland tumors arise from a t(11;19) rearrangement which generates a fusion oncogene, Mect1-Maml2, …
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Modi S, Kubo A, Oie H, Coxon AB, Rehmatulla A, Kaye FJ. Modi S, et al. Oncogene. 2000 Sep 21;19(40):4632-9. doi: 10.1038/sj.onc.1203815. Oncogene. 2000. PMID: 11030152
Mutational inactivation of the RB-related gene RBL2/p130 has been reported as a common and important prognostic factor in human lung cancer. ...While the RB/p16 tumor suppressor pathway is targeted for mutations in 100% of lung cancers, mutational inactivation of the relat …
Mutational inactivation of the RB-related gene RBL2/p130 has been reported as a common and important prognostic factor in human lung …
Temperature-sensitive RB mutations linked to incomplete penetrance of familial retinoblastoma in 12 families.
Otterson GA, Modi S, Nguyen K, Coxon AB, Kaye FJ. Otterson GA, et al. Am J Hum Genet. 1999 Oct;65(4):1040-6. doi: 10.1086/302581. Am J Hum Genet. 1999. PMID: 10486322 Free PMC article.
Although familial retinoblastoma is a paradigm for a highly penetrant, recessive model of tumorigenesis, the molecular basis for the phenotype of incomplete penetrance of familial retinoblastoma is undefined. ...The variable frequency for tumor development in these …
Although familial retinoblastoma is a paradigm for a highly penetrant, recessive model of tumorigenesis, the molecular basis f …
RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer.
Coxon AB, Ward JM, Geradts J, Otterson GA, Zajac-Kaye M, Kaye FJ. Coxon AB, et al. Oncogene. 1998 Sep 24;17(12):1625-8. doi: 10.1038/sj.onc.1202381. Oncogene. 1998. PMID: 9794240
Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple endocrine neoplasia-1 (MEN1) and MEN2 syndromes in humans, including medullary thyroid cancer (MTC). ...These mutations were localized to a
Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple en …
Incomplete penetrance of familial retinoblastoma linked to germ-line mutations that result in partial loss of RB function.
Otterson GA, Chen Wd, Coxon AB, Khleif SN, Kaye FJ. Otterson GA, et al. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12036-40. doi: 10.1073/pnas.94.22.12036. Proc Natl Acad Sci U S A. 1997. PMID: 9342358 Free PMC article.
In contrast, two low-penetrant alleles (661W and "deletion of codon 480") retained the ability to localize to the nucleus, showed normal cdk-mediated hyperphosphorylation in vivo, exhibited a binding pattern to simian virus 40 large T antigen using a quantitative ye …
In contrast, two low-penetrant alleles (661W and "deletion of codon 480") retained the ability to localize to the nucleus, showed normal cdk …
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