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Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation.
Craft S. Craft S. Neurobiol Aging. 2005 Dec;26 Suppl 1:65-9. doi: 10.1016/j.neurobiolaging.2005.08.021. Epub 2005 Nov 2. Neurobiol Aging. 2005. PMID: 16266773 Review.
The insulin resistance syndrome, characterized by chronic peripheral insulin elevations, reduced insulin activity, and reduced brain insulin levels, is associated with age-related memory impairment and Alzheimer's disease (AD). ...
The insulin resistance syndrome, characterized by chronic peripheral insulin elevations, reduced insulin activity, and reduced brain insulin …
Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages.
Neth BJ, Craft S. Neth BJ, et al. Among authors: craft s. Front Aging Neurosci. 2017 Oct 31;9:345. doi: 10.3389/fnagi.2017.00345. eCollection 2017. Front Aging Neurosci. 2017. PMID: 29163128 Free PMC article. Review.
Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced by brain glucose hypometabolism that can be observed potentially decades prior to the development of AD symptoms. ...
Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced by brain glucose hypometabolism that can b …
Insulin resistance predicts brain amyloid deposition in late middle-aged adults.
Willette AA, Johnson SC, Birdsill AC, Sager MA, Christian B, Baker LD, Craft S, Oh J, Statz E, Hermann BP, Jonaitis EM, Koscik RL, La Rue A, Asthana S, Bendlin BB. Willette AA, et al. Among authors: craft s. Alzheimers Dement. 2015 May;11(5):504-510.e1. doi: 10.1016/j.jalz.2014.03.011. Epub 2014 Jul 17. Alzheimers Dement. 2015. PMID: 25043908 Free PMC article.
BACKGROUND: Insulin resistance (IR) increases Alzheimer's disease (AD) risk. IR is related to greater amyloid burden post-mortem and increased deposition within areas affected by early AD. ...METHODS: Asymptomatic, late middle-aged adults (N = 186) from the Wisconsin Regis …
BACKGROUND: Insulin resistance (IR) increases Alzheimer's disease (AD) risk. IR is related to greater amyloid burden post-mortem and …
Insulin increases CSF Abeta42 levels in normal older adults.
Watson GS, Peskind ER, Asthana S, Purganan K, Wait C, Chapman D, Schwartz MW, Plymate S, Craft S. Watson GS, et al. Among authors: craft s. Neurology. 2003 Jun 24;60(12):1899-903. doi: 10.1212/01.wnl.0000065916.25128.25. Neurology. 2003. PMID: 12821730 Clinical Trial.
Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor.
Ling X, Martins RN, Racchi M, Craft S, Helmerhorst E. Ling X, et al. Among authors: craft s. J Alzheimers Dis. 2002 Oct;4(5):369-74. doi: 10.3233/jad-2002-4504. J Alzheimers Dis. 2002. PMID: 12446969
As evidence emerges concerning the role of insulin and insulin like growth factors (IGFs) in learning and memory, recent findings have suggested that insulin may have a significant role in the pathogenetic pathways leading to Alzheimer's disease (AD). ...
As evidence emerges concerning the role of insulin and insulin like growth factors (IGFs) in learning and memory, recent findings have sugge …
Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype.
Reger MA, Watson GS, Frey WH 2nd, Baker LD, Cholerton B, Keeling ML, Belongia DA, Fishel MA, Plymate SR, Schellenberg GD, Cherrier MM, Craft S. Reger MA, et al. Among authors: craft s. Neurobiol Aging. 2006 Mar;27(3):451-8. doi: 10.1016/j.neurobiolaging.2005.03.016. Epub 2005 Jun 16. Neurobiol Aging. 2006. PMID: 15964100 Clinical Trial.
On separate mornings, 26 memory-impaired subjects (13 with early Alzheimer's disease and 13 with amnestic mild cognitive impairment) and 35 normal controls each underwent three intranasal treatment conditions consisting of saline (placebo) or insulin (20 or 40 IU). ...
On separate mornings, 26 memory-impaired subjects (13 with early Alzheimer's disease and 13 with amnestic mild cognitive impairment) …
Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment.
Cherrier MM, Matsumoto AM, Amory JK, Asthana S, Bremner W, Peskind ER, Raskind MA, Craft S. Cherrier MM, et al. Among authors: craft s. Neurology. 2005 Jun 28;64(12):2063-8. doi: 10.1212/01.WNL.0000165995.98986.F1. Neurology. 2005. PMID: 15985573 Clinical Trial.
Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype.
Craft S, Asthana S, Schellenberg G, Baker L, Cherrier M, Boyt AA, Martins RN, Raskind M, Peskind E, Plymate S. Craft S, et al. Ann N Y Acad Sci. 2000 Apr;903:222-8. doi: 10.1111/j.1749-6632.2000.tb06371.x. Ann N Y Acad Sci. 2000. PMID: 10818510
Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimer's disease (AD) who do not possess an apolipoprotein E (ApoE)-epsilon 4 allele. ...
Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patie …
The effect of insulin and glucose on the plasma concentration of Alzheimer's amyloid precursor protein.
Boyt AA, Taddei TK, Hallmayer J, Helmerhorst E, Gandy SE, Craft S, Martins RN. Boyt AA, et al. Among authors: craft s. Neuroscience. 2000;95(3):727-34. doi: 10.1016/s0306-4522(99)00458-3. Neuroscience. 2000. PMID: 10670439
The deposition of beta amyloid is a critical event in the pathogenesis of Alzheimer's disease. This peptide is a metabolite of the amyloid precursor protein. Recent research suggests that there is a correlation between plasma insulin and glucose concentrations and memory p …
The deposition of beta amyloid is a critical event in the pathogenesis of Alzheimer's disease. This peptide is a metabolite of the am …
Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender.
Craft S, Asthana S, Schellenberg G, Cherrier M, Baker LD, Newcomer J, Plymate S, Latendresse S, Petrova A, Raskind M, Peskind E, Lofgreen C, Grimwood K. Craft S, et al. Neuroendocrinology. 1999 Aug;70(2):146-52. doi: 10.1159/000054469. Neuroendocrinology. 1999. PMID: 10461029 Clinical Trial.
Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimer's disease (AD) who do not possess an apolipoprotein E (APOE)-epsilon4 allele. ...
Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patie …
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