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1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells.
Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O'Garra A. Boonstra A, et al. Among authors: crain c. J Immunol. 2001 Nov 1;167(9):4974-80. doi: 10.4049/jimmunol.167.9.4974. J Immunol. 2001. PMID: 11673504
Using CD4(+)Mel14(+) T cells derived from mice on a BALB/c and a C57BL/6 genetic background we examined the effect of vitD3 on Th cell development. ...The enhanced Th2 development by vitD3 was found in both BALB/c and C57BL/6 mice. An increased expression of the Th2 …
Using CD4(+)Mel14(+) T cells derived from mice on a BALB/c and a C57BL/6 genetic background we examined the effect of vitD3 on Th cel …
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.
Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF, de Waal-Malefyt R, Coffman RL, Hawrylowicz CM, O'Garra A. Barrat FJ, et al. Among authors: crain c. J Exp Med. 2002 Mar 4;195(5):603-16. doi: 10.1084/jem.20011629. J Exp Med. 2002. PMID: 11877483 Free PMC article.
Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation.
Boonstra A, Asselin-Paturel C, Gilliet M, Crain C, Trinchieri G, Liu YJ, O'Garra A. Boonstra A, et al. Among authors: crain c. J Exp Med. 2003 Jan 6;197(1):101-9. doi: 10.1084/jem.20021908. J Exp Med. 2003. PMID: 12515817 Free PMC article.
Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma.
Heath VL, Showe L, Crain C, Barrat FJ, Trinchieri G, O'Garra A. Heath VL, et al. Among authors: crain c. J Immunol. 2000 Mar 15;164(6):2861-5. doi: 10.4049/jimmunol.164.6.2861. J Immunol. 2000. PMID: 10706670
TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression.
Heath VL, Murphy EE, Crain C, Tomlinson MG, O'Garra A. Heath VL, et al. Among authors: crain c. Eur J Immunol. 2000 Sep;30(9):2639-49. doi: 10.1002/1521-4141(200009)30:9<2639::AID-IMMU2639>3.0.CO;2-7. Eur J Immunol. 2000. PMID: 11009098
Chk1 is essential for tumor cell viability following activation of the replication checkpoint.
Cho SH, Toouli CD, Fujii GH, Crain C, Parry D. Cho SH, et al. Among authors: crain c. Cell Cycle. 2005 Jan;4(1):131-9. doi: 10.4161/cc.4.1.1299. Epub 2005 Jan 15. Cell Cycle. 2005. PMID: 15539958
In this manuscript we investigated the potential of chemo-sensitization via ablation of Chk1 in cells treated with anti-metabolite cancer drugs, hydroxyurea (HU) and cytosine arabinoside (ara-C). ...
In this manuscript we investigated the potential of chemo-sensitization via ablation of Chk1 in cells treated with anti-metabolite cancer dr …
RNA recognition by human TLR8 can lead to autoimmune inflammation.
Guiducci C, Gong M, Cepika AM, Xu Z, Tripodo C, Bennett L, Crain C, Quartier P, Cush JJ, Pascual V, Coffman RL, Barrat FJ. Guiducci C, et al. Among authors: crain c. J Exp Med. 2013 Dec 16;210(13):2903-19. doi: 10.1084/jem.20131044. Epub 2013 Nov 25. J Exp Med. 2013. PMID: 24277153 Free PMC article.
Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells.
Wang S, Campos J, Gallotta M, Gong M, Crain C, Naik E, Coffman RL, Guiducci C. Wang S, et al. Among authors: crain c. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7240-E7249. doi: 10.1073/pnas.1608555113. Epub 2016 Oct 31. Proc Natl Acad Sci U S A. 2016. PMID: 27799536 Free PMC article.
The Impact of an Adolescent Gynecology Provider on Intrauterine Device and Subdermal Contraceptive Implant Use Among Adolescent Patients.
Crain CL, DeFruscio AE, Shah PT, Hunt L, Yoost JL. Crain CL, et al. J Pediatr Adolesc Gynecol. 2020 Feb 19:S1083-3188(20)30157-1. doi: 10.1016/j.jpag.2020.02.004. Online ahead of print. J Pediatr Adolesc Gynecol. 2020. PMID: 32087404
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