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Page 1
Predicting the mutations generated by repair of Cas9-induced double-strand breaks.
Allen F, Crepaldi L, Alsinet C, Strong AJ, Kleshchevnikov V, De Angeli P, Páleníková P, Khodak A, Kiselev V, Kosicki M, Bassett AR, Harding H, Galanty Y, Muñoz-Martínez F, Metzakopian E, Jackson SP, Parts L. Allen F, et al. Nat Biotechnol. 2018 Nov 27:10.1038/nbt.4317. doi: 10.1038/nbt.4317. Online ahead of print. Nat Biotechnol. 2018. PMID: 30480667 Free PMC article.
The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations.
Pallaseni A, Peets EM, Girling G, Crepaldi L, Kuzmin I, Moor M, Muñoz-Subirana N, Schimmel J, Serçin Ö, Mardin BR, Tijsterman M, Peterson H, Kosicki M, Parts L. Pallaseni A, et al. bioRxiv [Preprint]. 2024 Sep 14:2023.06.28.546891. doi: 10.1101/2023.06.28.546891. bioRxiv. 2024. Update in: Nat Commun. 2024 Nov 27;15(1):10271. doi: 10.1038/s41467-024-54566-7. PMID: 37425722 Free PMC article. Updated. Preprint.
A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines.
Feng C, Peets EM, Zhou Y, Crepaldi L, Usluer S, Dunham A, Braunger JM, Su J, Strauss ME, Muraro D, Xian Cheam KA, Bonder MJ, Nogales EG, Cooper S, Bassett A, Leonard S, Gu Y, Fussing B, Burke D, Parts L, Stegle O, Velten B. Feng C, et al. Among authors: crepaldi l. Cell Genom. 2026 Feb 11;6(2):101076. doi: 10.1016/j.xgen.2025.101076. Epub 2025 Dec 1. Cell Genom. 2026. PMID: 41330380 Free PMC article.
P2X7 receptor blockade during Cryptococcus neoformans infection promotes a Th2-associated immune profile and enhances fungal dissemination to the brain.
Braga ICDC, Alves V, Araujo GRS, Crepaldi LD, Oliveira-Cruz L, da Silva MSP, de Souza Serra SS, Cristina-Rodrigues F, Alves VS, Coutinho-Silva R, Frases S, Cruz FF, Morales MM, Savio LEB. Braga ICDC, et al. Among authors: crepaldi ld. Int Immunopharmacol. 2026 Aug 15;183:116881. doi: 10.1016/j.intimp.2026.116881. Epub 2026 May 23. Int Immunopharmacol. 2026. PMID: 42172895
Enhanced citrate consumption increases colon permeability in C57BL/6J mice by affecting gut microbiota and activating HIF-1α.
Costa-Bartuli E, Paixão LP, Crepaldi LD, da Fonseca R, Vianna M, Moraes-Ribeiro R, Lima GV, Nascimento Junior JXD, Branco JR, Caldas CAG, Belo TCA, Takiya CM, de Almeida LA, Zancan P, Sola-Penna M. Costa-Bartuli E, et al. Among authors: crepaldi ld. J Nutr Biochem. 2025 Sep;143:109942. doi: 10.1016/j.jnutbio.2025.109942. Epub 2025 May 2. J Nutr Biochem. 2025. PMID: 40320183
66 results