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Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors.
Crewe HK, Barter ZE, Yeo KR, Rostami-Hodjegan A. Crewe HK, et al. Biopharm Drug Dispos. 2011 Sep;32(6):303-18. doi: 10.1002/bdd.760. Epub 2011 Jul 4. Biopharm Drug Dispos. 2011. PMID: 21725985
Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.
Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM. Crewe HK, et al. Drug Metab Dispos. 2002 Aug;30(8):869-74. doi: 10.1124/dmd.30.8.869. Drug Metab Dispos. 2002. PMID: 12124303
CYP2D6 is primarily responsible for the metabolism of clomiphene.
Ghobadi C, Gregory A, Crewe HK, Rostami-Hodjegan A, Lennard MS. Ghobadi C, et al. Among authors: crewe hk. Drug Metab Pharmacokinet. 2008;23(2):101-5. doi: 10.2133/dmpk.23.101. Drug Metab Pharmacokinet. 2008. PMID: 18445989 Free article.
The absorption kinetics of ketoconazole plays a major role in explaining the reported variability in the level of interaction with midazolam: Interplay between formulation and inhibition of gut wall and liver metabolism.
Liu B, Crewe HK, Ozdemir M, Rowland Yeo K, Tucker G, Rostami-Hodjegan A. Liu B, et al. Among authors: crewe hk. Biopharm Drug Dispos. 2017 Apr;38(3):260-270. doi: 10.1002/bdd.2058. Epub 2017 Feb 14. Biopharm Drug Dispos. 2017. PMID: 28004396
Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes.
Otton SV, Crewe HK, Lennard MS, Tucker GT, Woods HF. Otton SV, et al. Among authors: crewe hk. J Pharmacol Exp Ther. 1988 Oct;247(1):242-7. J Pharmacol Exp Ther. 1988. PMID: 3171974
Histamine inhibition of mixed function oxidase activity in rat and human liver microsomes and in the isolated perfused rat liver.
Morris CQ, Tucker GT, Crewe HK, Harlow JR, Woods HF, Lennard MS. Morris CQ, et al. Among authors: crewe hk. Biochem Pharmacol. 1989 Aug 15;38(16):2639-44. doi: 10.1016/0006-2952(89)90549-2. Biochem Pharmacol. 1989. PMID: 2764987
The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.
Crewe HK, Lennard MS, Tucker GT, Woods FR, Haddock RE. Crewe HK, et al. Br J Clin Pharmacol. 1992 Sep;34(3):262-5. doi: 10.1111/j.1365-2125.1992.tb04134.x. Br J Clin Pharmacol. 1992. PMID: 1389951 Free PMC article.
Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes.
Crewe HK, Ellis SW, Lennard MS, Tucker GT. Crewe HK, et al. Biochem Pharmacol. 1997 Jan 24;53(2):171-8. doi: 10.1016/s0006-2952(96)00650-8. Biochem Pharmacol. 1997. PMID: 9037249
mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates.
Graham MJ, Bell AR, Crewe HK, Moorcraft CL, Walker L, Whittaker EF, Lennard MS. Graham MJ, et al. Among authors: crewe hk. Xenobiotica. 2003 Mar;33(3):225-37. doi: 10.1080/0049825021000048782. Xenobiotica. 2003. PMID: 12637241
Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis.
Burt HJ, Riedmaier AE, Harwood MD, Crewe HK, Gill KL, Neuhoff S. Burt HJ, et al. Among authors: crewe hk. Drug Metab Dispos. 2016 Oct;44(10):1550-61. doi: 10.1124/dmd.116.071183. Epub 2016 Aug 4. Drug Metab Dispos. 2016. PMID: 27493152 Free PMC article.
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