Crews CM - Search Results

1

Catalytic in vivo protein knockdown by small-molecule PROTACs.

Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, Mulholland KE, Routly N, Buckley DL, Gustafson JL, Zinn N, Grandi P, Shimamura S, Bergamini G, Faelth-Savitski M, Bantscheff M, Cox C, Gordon DA, Willard RR, Flanagan JJ, Casillas LN, Votta BJ, den Besten W, Famm K, Kruidenier L, Carter PS, Harling JD, Churcher I, Crews CM. Bondeson DP, et al. Among authors: crews cm. Nat Chem Biol. 2015 Aug;11(8):611-7. doi: 10.1038/nchembio.1858. Epub 2015 Jun 10. Nat Chem Biol. 2015. PMID: 26075522 Free PMC article.

2

Small-molecule inhibitors of the cell cycle.

Crews CM, Mohan R. Crews CM, et al. Curr Opin Chem Biol. 2000 Feb;4(1):47-53. doi: 10.1016/s1367-5931(99)00050-2. Curr Opin Chem Biol. 2000. PMID: 10679374 Free article. Review.

3

Chemical genetic control of protein levels: selective in vivo targeted degradation.

Schneekloth JS Jr, Fonseca FN, Koldobskiy M, Mandal A, Deshaies R, Sakamoto K, Crews CM. Schneekloth JS Jr, et al. Among authors: crews cm. J Am Chem Soc. 2004 Mar 31;126(12):3748-54. doi: 10.1021/ja039025z. J Am Chem Soc. 2004. PMID: 15038727 Free article.

4

Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.

Corson TW, Aberle N, Crews CM. Corson TW, et al. Among authors: crews cm. ACS Chem Biol. 2008 Nov 21;3(11):677-692. doi: 10.1021/cb8001792. ACS Chem Biol. 2008. PMID: 19112665 Free PMC article. Review.

5

Targeting the undruggable proteome: the small molecules of my dreams.

Crews CM. Crews CM. Chem Biol. 2010 Jun 25;17(6):551-5. doi: 10.1016/j.chembiol.2010.05.011. Chem Biol. 2010. PMID: 20609404 Free PMC article. Review.

6

HIV protease-mediated activation of sterically capped proteasome inhibitors and substrates.

Buckley DL, Corson TW, Aberle N, Crews CM. Buckley DL, et al. Among authors: crews cm. J Am Chem Soc. 2011 Feb 2;133(4):698-700. doi: 10.1021/ja109377p. J Am Chem Soc. 2011. PMID: 21186803

7

Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins.

Neklesa TK, Tae HS, Schneekloth AR, Stulberg MJ, Corson TW, Sundberg TB, Raina K, Holley SA, Crews CM. Neklesa TK, et al. Among authors: crews cm. Nat Chem Biol. 2011 Jul 3;7(8):538-43. doi: 10.1038/nchembio.597. Nat Chem Biol. 2011. PMID: 21725302 Free PMC article.

8

Identification of hydrophobic tags for the degradation of stabilized proteins.

Tae HS, Sundberg TB, Neklesa TK, Noblin DJ, Gustafson JL, Roth AG, Raina K, Crews CM. Tae HS, et al. Among authors: crews cm. Chembiochem. 2012 Mar 5;13(4):538-41. doi: 10.1002/cbic.201100793. Epub 2012 Jan 23. Chembiochem. 2012. PMID: 22271667 Free PMC article.

9

Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction.

Buckley DL, Van Molle I, Gareiss PC, Tae HS, Michel J, Noblin DJ, Jorgensen WL, Ciulli A, Crews CM. Buckley DL, et al. Among authors: crews cm. J Am Chem Soc. 2012 Mar 14;134(10):4465-8. doi: 10.1021/ja209924v. Epub 2012 Feb 27. J Am Chem Soc. 2012. PMID: 22369643 Free PMC article.

10

A HaloTag-based small molecule microarray screening methodology with increased sensitivity and multiplex capabilities.

Noblin DJ, Page CM, Tae HS, Gareiss PC, Schneekloth JS, Crews CM. Noblin DJ, et al. Among authors: crews cm. ACS Chem Biol. 2012 Dec 21;7(12):2055-63. doi: 10.1021/cb300453k. Epub 2012 Oct 11. ACS Chem Biol. 2012. PMID: 23013033 Free PMC article.

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