Positron emission tomography scan to determine the need for neck dissection after chemoradiation for head and neck cancer: timing is everything

Laryngoscope. 2005 Dec;115(12):2206-8. doi: 10.1097/01.mlg.0000182829.71310.ae.

Abstract

We present a case of a negative positron emission tomography (PET) scan in a patient with pathologic viable cancer at neck dissection.

Study design: Case Report.

Methods: A 69-year-old man presented with clinical stage T2N2c squamous cell cancer of the left tonsil and was treated with definitive chemoradiation. Left-sided adenopathy decreased but remained palpable after therapy.

Results: PET scan performed 23 days after completion of treatment showed no suspicious uptake in the left neck. Neck dissection performed at 2 months post-therapy revealed viable tumor in left cervical nodes.

Conclusions: Persistent adenopathy after chemoradiation for head and neck cancer remains a clinical dilemma. A negative PET scan is accurate but only if the scan is performed 3 to 4 months after therapy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antimetabolites, Antineoplastic / therapeutic use*
  • Antineoplastic Agents / therapeutic use*
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / radiotherapy
  • Carcinoma, Squamous Cell / secondary
  • Carcinoma, Squamous Cell / therapy*
  • Chemotherapy, Adjuvant
  • Cisplatin / therapeutic use
  • Drug Therapy, Combination
  • Fluorouracil / therapeutic use
  • Follow-Up Studies
  • Humans
  • Lymphatic Metastasis
  • Male
  • Neck / diagnostic imaging*
  • Neck Dissection / methods*
  • Time Factors
  • Tomography, X-Ray Computed*
  • Tonsillar Neoplasms / drug therapy
  • Tonsillar Neoplasms / pathology
  • Tonsillar Neoplasms / radiotherapy
  • Tonsillar Neoplasms / therapy*

Substances

  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Cisplatin
  • Fluorouracil