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Crystal structure of an Xrcc4-DNA ligase IV complex.
Sibanda BL, Critchlow SE, Begun J, Pei XY, Jackson SP, Blundell TL, Pellegrini L. Sibanda BL, et al. Among authors: critchlow se. Nat Struct Biol. 2001 Dec;8(12):1015-9. doi: 10.1038/nsb725. Nat Struct Biol. 2001. PMID: 11702069
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient.
Riballo E, Critchlow SE, Teo SH, Doherty AJ, Priestley A, Broughton B, Kysela B, Beamish H, Plowman N, Arlett CF, Lehmann AR, Jackson SP, Jeggo PA. Riballo E, et al. Among authors: critchlow se. Curr Biol. 1999 Jul 1;9(13):699-702. doi: 10.1016/s0960-9822(99)80311-x. Curr Biol. 1999. PMID: 10395545
DNA end-joining: from yeast to man.
Critchlow SE, Jackson SP. Critchlow SE, et al. Trends Biochem Sci. 1998 Oct;23(10):394-8. doi: 10.1016/s0968-0004(98)01284-5. Trends Biochem Sci. 1998. PMID: 9810228 Review.
3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers.
Jones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO, Critchlow SE, Schulze A, Gottlieb E, Wakelam MJO, Harris AL. Jones DT, et al. Among authors: critchlow se. Mol Cancer Ther. 2019 Feb;18(2):376-388. doi: 10.1158/1535-7163.MCT-17-0857. Epub 2018 Nov 26. Mol Cancer Ther. 2019. PMID: 30478149 Free PMC article.
Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors.
Lynch JT, Polanska UM, Delpuech O, Hancox U, Trinidad AG, Michopoulos F, Lenaghan C, McEwen R, Bradford J, Polanski R, Ellston R, Avivar-Valderas A, Pilling J, Staniszewska A, Cumberbatch M, Critchlow SE, Cruzalegui F, Barry ST. Lynch JT, et al. Among authors: critchlow se. Clin Cancer Res. 2017 Dec 15;23(24):7584-7595. doi: 10.1158/1078-0432.CCR-17-0676. Epub 2017 Oct 2. Clin Cancer Res. 2017. PMID: 28972046 Free article.
Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.
Kettle JG, Ballard P, Bardelle C, Cockerill M, Colclough N, Critchlow SE, Debreczeni J, Fairley G, Fillery S, Graham MA, Goodwin L, Guichard S, Hudson K, Ward RA, Whittaker D. Kettle JG, et al. Among authors: critchlow se. J Med Chem. 2015 Mar 26;58(6):2834-44. doi: 10.1021/acs.jmedchem.5b00098. Epub 2015 Mar 12. J Med Chem. 2015. PMID: 25738750
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