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Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer.
McGregor JM, Harwood CA, Brooks L, Fisher SA, Kelly DA, O'nions J, Young AR, Surentheran T, Breuer J, Millard TP, Lewis CM, Leigh IM, Storey A, Crook T. McGregor JM, et al. J Invest Dermatol. 2002 Jul;119(1):84-90. doi: 10.1046/j.1523-1747.2002.01655.x. J Invest Dermatol. 2002. PMID: 12164929
Posttransplant skin cancer: a possible role for p53 gene mutation but not for oncogenic human papillomaviruses.
McGregor JM, Farthing A, Crook T, Yu CC, Dublin EA, Levison DA, MacDonald DM. McGregor JM, et al. J Am Acad Dermatol. 1994 May;30(5 Pt 1):701-6. doi: 10.1016/s0190-9622(08)81498-3. J Am Acad Dermatol. 1994. PMID: 8176007
p73 is over-expressed in vulval cancer principally as the Delta 2 isoform.
O'Nions J, Brooks LA, Sullivan A, Bell A, Dunne B, Rozycka M, Reddy A, Tidy JA, Evans D, Farrell PJ, Evans A, Gasco M, Gusterson B, Crook T. O'Nions J, et al. Br J Cancer. 2001 Nov 16;85(10):1551-6. doi: 10.1054/bjoc.2001.2138. Br J Cancer. 2001. PMID: 11720444 Free PMC article.
Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma.
Anderton E, Yee J, Smith P, Crook T, White RE, Allday MJ. Anderton E, et al. Oncogene. 2008 Jan 17;27(4):421-33. doi: 10.1038/sj.onc.1210668. Epub 2007 Jul 23. Oncogene. 2008. PMID: 17653091
p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements.
Campomenosi P, Monti P, Aprile A, Abbondandolo A, Frebourg T, Gold B, Crook T, Inga A, Resnick MA, Iggo R, Fronza G. Campomenosi P, et al. Oncogene. 2001 Jun 14;20(27):3573-9. doi: 10.1038/sj.onc.1204468. Oncogene. 2001. PMID: 11429705
ASPP proteins specifically stimulate the apoptotic function of p53.
Samuels-Lev Y, O'Connor DJ, Bergamaschi D, Trigiante G, Hsieh JK, Zhong S, Campargue I, Naumovski L, Crook T, Lu X. Samuels-Lev Y, et al. Mol Cell. 2001 Oct;8(4):781-94. doi: 10.1016/s1097-2765(01)00367-7. Mol Cell. 2001. PMID: 11684014
Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus.
Brooks LA, Tidy JA, Gusterson B, Hiller L, O'Nions J, Gasco M, Marin MC, Farrell PJ, Kaelin WG Jr, Crook T. Brooks LA, et al. Cancer Res. 2000 Dec 15;60(24):6875-7. Cancer Res. 2000. PMID: 11156383
A common polymorphism acts as an intragenic modifier of mutant p53 behaviour.
Marin MC, Jost CA, Brooks LA, Irwin MS, O'Nions J, Tidy JA, James N, McGregor JM, Harwood CA, Yulug IG, Vousden KH, Allday MJ, Gusterson B, Ikawa S, Hinds PW, Crook T, Kaelin WG Jr. Marin MC, et al. Nat Genet. 2000 May;25(1):47-54. doi: 10.1038/75586. Nat Genet. 2000. PMID: 10802655
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