Crooks PA - Search Results

1

Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases.

Balasubramaniam M, Ayyadevara S, Ganne A, Kakraba S, Penthala NR, Du X, Crooks PA, Griffin ST, Shmookler Reis RJ. Balasubramaniam M, et al. Among authors: crooks pa. iScience. 2019 Oct 25;20:248-264. doi: 10.1016/j.isci.2019.09.026. Epub 2019 Sep 21. iScience. 2019. PMID: 31593839 Free PMC article.

2

A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease.

Kakraba S, Ayyadevara S, Penthala NR, Balasubramaniam M, Ganne A, Liu L, Alla R, Bommagani SB, Barger SW, Griffin WST, Crooks PA, Shmookler Reis RJ. Kakraba S, et al. Among authors: crooks pa. Front Mol Neurosci. 2019 Dec 12;12:310. doi: 10.3389/fnmol.2019.00310. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31920540 Free PMC article.

3

Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation.

Bowroju SK, Mainali N, Ayyadevara S, Penthala NR, Krishnamachari S, Kakraba S, Reis RJS, Crooks PA. Bowroju SK, et al. Among authors: crooks pa. Molecules. 2020 Aug 8;25(16):3610. doi: 10.3390/molecules25163610. Molecules. 2020. PMID: 32784464 Free PMC article.

4

rac-5-Bromo-N-benzyl-isatincreatinine ethanol monosolvate.

Penthala NR, Crooks PA. Penthala NR, et al. Among authors: crooks pa. Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 1;69(Pt 2):o288-9. doi: 10.1107/S160053681300038X. Epub 2013 Jan 26. Acta Crystallogr Sect E Struct Rep Online. 2013. PMID: 23424559 Free PMC article.

5

rac-N-Benzyl-isatincreatinine (unknown solvate).

Penthala NR, Crooks PA. Penthala NR, et al. Among authors: crooks pa. Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 1;69(Pt 2):o290-1. doi: 10.1107/S1600536813000378. Epub 2013 Jan 26. Acta Crystallogr Sect E Struct Rep Online. 2013. PMID: 23424560 Free PMC article.

6

Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents.

Penthala NR, Thakkar S, Crooks PA. Penthala NR, et al. Among authors: crooks pa. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2763-7. doi: 10.1016/j.bmcl.2015.05.019. Epub 2015 May 16. Bioorg Med Chem Lett. 2015. PMID: 26022840 Free PMC article.

7

Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs.

Balasubramaniam M, Mainali N, Bowroju SK, Atluri P, Penthala NR, Ayyadevera S, Crooks PA, Shmookler Reis RJ. Balasubramaniam M, et al. Among authors: crooks pa. Sci Rep. 2020 Oct 27;10(1):18326. doi: 10.1038/s41598-020-75020-w. Sci Rep. 2020. PMID: 33110096 Free PMC article.

8

Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.

Bowroju SK, Penthala NR, Lakkaniga NR, Balasubramaniam M, Ayyadevara S, Shmookler Reis RJ, Crooks PA. Bowroju SK, et al. Among authors: crooks pa. Bioorg Med Chem. 2021 Sep 1;45:116311. doi: 10.1016/j.bmc.2021.116311. Epub 2021 Jul 14. Bioorg Med Chem. 2021. PMID: 34304133 Free PMC article.

9

rac-(Z)-Methyl 1-benzyl-3-[(3-hy-droxy-quinuclidin-2-yl-idene)meth-yl]-1H-indole-6-carboxyl-ate.

Penthala NR, Ponugoti PR, Parkin S, Crooks PA. Penthala NR, et al. Among authors: crooks pa. Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3111. doi: 10.1107/S1600536812040731. Epub 2012 Oct 13. Acta Crystallogr Sect E Struct Rep Online. 2012. PMID: 23284437 Free PMC article.

10

Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines.

Madadi NR, Penthala NR, Janganati V, Crooks PA. Madadi NR, et al. Among authors: crooks pa. Bioorg Med Chem Lett. 2014 Jan 15;24(2):601-3. doi: 10.1016/j.bmcl.2013.12.013. Epub 2013 Dec 9. Bioorg Med Chem Lett. 2014. PMID: 24361000 Free PMC article.

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