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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Cross DA, et al. Nature. 1995 Dec 21-28;378(6559):785-9. doi: 10.1038/378785a0. Nature. 1995. PMID: 8524413
FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A.
Hagen T, Cross DA, Culbert AA, West A, Frame S, Morrice N, Reith AD. Hagen T, et al. J Biol Chem. 2006 Nov 17;281(46):35021-9. doi: 10.1074/jbc.M607003200. Epub 2006 Sep 18. J Biol Chem. 2006. PMID: 16982607
Assays for glycogen synthase kinase-3 (GSK-3).
Cross D. Cross D. Methods Mol Biol. 2001;124:147-59. doi: 10.1385/1-59259-059-4:147. Methods Mol Biol. 2001. PMID: 11100473 No abstract available.
Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.
Sommer EM, Dry H, Cross D, Guichard S, Davies BR, Alessi DR. Sommer EM, et al. Biochem J. 2013 Jun 15;452(3):499-508. doi: 10.1042/BJ20130342. Biochem J. 2013. PMID: 23581296 Free PMC article.
Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.
Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, Shpiro N, Ward R, Cross D, Ganley IG, Alessi DR. Bago R, et al. Biochem J. 2014 Nov 1;463(3):413-27. doi: 10.1042/BJ20140889. Biochem J. 2014. PMID: 25177796 Free PMC article.
The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.
Bago R, Sommer E, Castel P, Crafter C, Bailey FP, Shpiro N, Baselga J, Cross D, Eyers PA, Alessi DR. Bago R, et al. EMBO J. 2016 Sep 1;35(17):1902-22. doi: 10.15252/embj.201693929. Epub 2016 Aug 1. EMBO J. 2016. PMID: 27481935 Free PMC article.
PDK1, one of the missing links in insulin signal transduction?
Cohen P, Alessi DR, Cross DA. Cohen P, et al. FEBS Lett. 1997 Jun 23;410(1):3-10. doi: 10.1016/s0014-5793(97)00490-0. FEBS Lett. 1997. PMID: 9247112 Review.
Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue.
Cross DA, Watt PW, Shaw M, van der Kaay J, Downes CP, Holder JC, Cohen P. Cross DA, et al. FEBS Lett. 1997 Apr 7;406(1-2):211-5. doi: 10.1016/s0014-5793(97)00240-8. FEBS Lett. 1997. PMID: 9109420
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