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Rb is critical in a mammalian tissue stem cell population.
Wenzel PL, Wu L, de Bruin A, Chong JL, Chen WY, Dureska G, Sites E, Pan T, Sharma A, Huang K, Ridgway R, Mosaliganti K, Sharp R, Machiraju R, Saltz J, Yamamoto H, Cross JC, Robinson ML, Leone G. Wenzel PL, et al. Among authors: cross jc. Genes Dev. 2007 Jan 1;21(1):85-97. doi: 10.1101/gad.1485307. Genes Dev. 2007. PMID: 17210791 Free PMC article.
Extra-embryonic function of Rb is essential for embryonic development and viability.
Wu L, de Bruin A, Saavedra HI, Starovic M, Trimboli A, Yang Y, Opavska J, Wilson P, Thompson JC, Ostrowski MC, Rosol TJ, Woollett LA, Weinstein M, Cross JC, Robinson ML, Leone G. Wu L, et al. Among authors: cross jc. Nature. 2003 Feb 27;421(6926):942-7. doi: 10.1038/nature01417. Nature. 2003. PMID: 12607001
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