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ATP-citrate lyase links cellular metabolism to histone acetylation.
Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. Wellen KE, et al. Among authors: cross jr. Science. 2009 May 22;324(5930):1076-80. doi: 10.1126/science.1164097. Science. 2009. PMID: 19461003 Free PMC article.
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB. Ward PS, et al. Among authors: cross jr. Cancer Cell. 2010 Mar 16;17(3):225-34. doi: 10.1016/j.ccr.2010.01.020. Epub 2010 Feb 18. Cancer Cell. 2010. PMID: 20171147 Free PMC article.
Induction of sarcomas by mutant IDH2.
Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, Healey JH, Lowe SW, Schwartz GK, Melnick A, Thompson CB. Lu C, et al. Among authors: cross jr. Genes Dev. 2013 Sep 15;27(18):1986-98. doi: 10.1101/gad.226753.113. Genes Dev. 2013. PMID: 24065766 Free PMC article.
PTEN is a protein tyrosine phosphatase for IRS1.
Shi Y, Wang J, Chandarlapaty S, Cross J, Thompson C, Rosen N, Jiang X. Shi Y, et al. Nat Struct Mol Biol. 2014 Jun;21(6):522-7. doi: 10.1038/nsmb.2828. Epub 2014 May 11. Nat Struct Mol Biol. 2014. PMID: 24814346 Free PMC article.
Serine catabolism regulates mitochondrial redox control during hypoxia.
Ye J, Fan J, Venneti S, Wan YW, Pawel BR, Zhang J, Finley LW, Lu C, Lindsten T, Cross JR, Qing G, Liu Z, Simon MC, Rabinowitz JD, Thompson CB. Ye J, et al. Among authors: cross jr. Cancer Discov. 2014 Dec;4(12):1406-17. doi: 10.1158/2159-8290.CD-14-0250. Epub 2014 Sep 3. Cancer Discov. 2014. PMID: 25186948 Free PMC article.
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Zhang J, Fan J, Venneti S, Cross JR, Takagi T, Bhinder B, Djaballah H, Kanai M, Cheng EH, Judkins AR, Pawel B, Baggs J, Cherry S, Rabinowitz JD, Thompson CB. Zhang J, et al. Among authors: cross jr. Mol Cell. 2014 Oct 23;56(2):205-218. doi: 10.1016/j.molcel.2014.08.018. Epub 2014 Sep 18. Mol Cell. 2014. PMID: 25242145 Free PMC article.
206 results