Cross PJ - Search Results

1

Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain.

Cross PJ, Allison TM, Dobson RC, Jameson GB, Parker EJ. Cross PJ, et al. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2111-6. doi: 10.1073/pnas.1217923110. Epub 2013 Jan 23. Proc Natl Acad Sci U S A. 2013. PMID: 23345433 Free PMC article.

2

Exploring modular allostery via interchangeable regulatory domains.

Fan Y, Cross PJ, Jameson GB, Parker EJ. Fan Y, et al. Among authors: cross pj. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3006-3011. doi: 10.1073/pnas.1717621115. Epub 2018 Mar 5. Proc Natl Acad Sci U S A. 2018. PMID: 29507215 Free PMC article.

3

First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer.

Arturo EC, Gupta K, Héroux A, Stith L, Cross PJ, Parker EJ, Loll PJ, Jaffe EK. Arturo EC, et al. Among authors: cross pj. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2394-9. doi: 10.1073/pnas.1516967113. Epub 2016 Feb 16. Proc Natl Acad Sci U S A. 2016. PMID: 26884182 Free PMC article.

4

The Functional Unit of Neisseria meningitidis 3-Deoxy-ᴅ-Arabino-Heptulosonate 7-Phosphate Synthase Is Dimeric.

Cross PJ, Heyes LC, Zhang S, Nazmi AR, Parker EJ. Cross PJ, et al. PLoS One. 2016 Feb 1;11(2):e0145187. doi: 10.1371/journal.pone.0145187. eCollection 2016. PLoS One. 2016. PMID: 26828675 Free PMC article.

5

Allosteric ACTion: the varied ACT domains regulating enzymes of amino-acid metabolism.

Lang EJ, Cross PJ, Mittelstädt G, Jameson GB, Parker EJ. Lang EJ, et al. Among authors: cross pj. Curr Opin Struct Biol. 2014 Dec;29:102-11. doi: 10.1016/j.sbi.2014.10.007. Epub 2014 Nov 21. Curr Opin Struct Biol. 2014. PMID: 25543886 Review.

6

Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase - The importance of accommodating the active site water.

Heyes LC, Reichau S, Cross PJ, Jameson GB, Parker EJ. Heyes LC, et al. Among authors: cross pj. Bioorg Chem. 2014 Dec;57:242-250. doi: 10.1016/j.bioorg.2014.08.003. Epub 2014 Aug 27. Bioorg Chem. 2014. PMID: 25245459

7

Allosteric inhibitor specificity of Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.

Cross PJ, Parker EJ. Cross PJ, et al. FEBS Lett. 2013 Sep 17;587(18):3063-8. doi: 10.1016/j.febslet.2013.07.044. Epub 2013 Jul 31. FEBS Lett. 2013. PMID: 23916814 Free article.

8

Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine.

Cross PJ, Pietersma AL, Allison TM, Wilson-Coutts SM, Cochrane FC, Parker EJ. Cross PJ, et al. Protein Sci. 2013 Aug;22(8):1087-99. doi: 10.1002/pro.2293. Epub 2013 Jun 27. Protein Sci. 2013. PMID: 23754471 Free PMC article.

9

Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis.

Cross PJ, Dobson RC, Patchett ML, Parker EJ. Cross PJ, et al. J Biol Chem. 2011 Mar 25;286(12):10216-24. doi: 10.1074/jbc.M110.209924. Epub 2011 Jan 30. J Biol Chem. 2011. PMID: 21282100 Free PMC article.

10

Dynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allostery.

Jiao W, Hutton RD, Cross PJ, Jameson GB, Parker EJ. Jiao W, et al. Among authors: cross pj. J Mol Biol. 2012 Jan 27;415(4):716-26. doi: 10.1016/j.jmb.2011.11.037. Epub 2011 Dec 2. J Mol Biol. 2012. PMID: 22154807

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