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Cross-phenotype associations between Alzheimer's Disease and its comorbidities may provide clues to progression.
Moore A, Ritchie MD. Moore A, et al. medRxiv [Preprint]. 2023 Nov 7:2023.11.06.23297993. doi: 10.1101/2023.11.06.23297993. medRxiv. 2023. Update in: AMIA Jt Summits Transl Sci Proc. 2024 May 31;2024:623-631. PMID: 37986758 Free PMC article. Updated. Preprint.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide, with one in nine people over the age of 65 living with the disease in 2023. ...Based on 497 previously identified AD-associated variants from the Alzhe …
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide, with one in nine people over …
Cross-phenotype associations between Alzheimer's Disease and its comorbidities may provide clues to progression.
Moore A, Ritchie MD. Moore A, et al. AMIA Jt Summits Transl Sci Proc. 2024 May 31;2024:623-631. eCollection 2024. AMIA Jt Summits Transl Sci Proc. 2024. PMID: 38827078 Free PMC article.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide, with one in nine people over the age of 65 living with the disease in 2023. ...Based on 497 previously identified AD-associated variants from the Alzhe …
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide, with one in nine people over …
Exploring Synaptic Pathways in Traumatic Brain Injury: A Cross-Phenotype Genomics Approach.
Prapiadou S, Mayerhofer E, Georgakis MK, Kals M, Radmanesh F, Izzy S, Richardson S, Okonkwo D, Puccio A, Temkin N, Palotie A, Ripatti S, Diaz-Arrastia R, Stein MB, Manley G, Menon DK, Rosand J, Parodi L, Anderson CD; Genetic Associations In Neurotrauma (GAIN) Consortium (with contribution from the CENTER-TBI, TRACK-TBI, CABI, MGB, and TBIcare studies). Prapiadou S, et al. J Neurotrauma. 2024 Oct 7. doi: 10.1089/neu.2024.0153. Online ahead of print. J Neurotrauma. 2024. PMID: 39264867
We leveraged an integrative approach, combining data from genome-wide association studies with pathway and gene-set enrichment analyses. Literature review-based and Reactome database-driven approaches were combined to identify synapse-related pathways of interest in TBI ou …
We leveraged an integrative approach, combining data from genome-wide association studies with pathway and gene-set enrichment analys …
Investigating the genetic relationship between Alzheimer's disease and cancer using GWAS summary statistics.
Feng YA, Cho K, Lindstrom S, Kraft P, Cormack J; IGAP Consortium, Colorectal Transdisciplinary Study (CORECT); Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE); Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE); Transdisciplinary Research in Cancer of the Lung (TRICL); Liang L, Driver JA. Feng YA, et al. Hum Genet. 2017 Oct;136(10):1341-1351. doi: 10.1007/s00439-017-1831-6. Epub 2017 Aug 5. Hum Genet. 2017. PMID: 28780673 Free PMC article.
Growing evidence from both epidemiology and basic science suggest an inverse association between Alzheimer's disease (AD) and cancer. We examined the genetic relationship between AD and various cancer types using GWAS summary statistics from the IGAP a …
Growing evidence from both epidemiology and basic science suggest an inverse association between Alzheimer's disease …
Sleep and Late-Onset Alzheimer's Disease: Shared Genetic Risk Factors, Drug Targets, Molecular Mechanisms, and Causal Effects.
Chen D, Wang X, Huang T, Jia J. Chen D, et al. Front Genet. 2022 May 17;13:794202. doi: 10.3389/fgene.2022.794202. eCollection 2022. Front Genet. 2022. PMID: 35656316 Free PMC article.
Late-onset Alzheimer's disease (AD) is associated with sleep-related phenotypes (SRPs). The fact that whether they share a common genetic etiology remains largely unknown. We explored the shared genetics and causality between AD and SRPs by using high- …
Late-onset Alzheimer's disease (AD) is associated with sleep-related phenotypes (SRPs). The fact that whether th …
Collagenous Colitis Is Associated With HLA Signature and Shares Genetic Risks With Other Immune-Mediated Diseases.
Stahl E, Roda G, Dobbyn A, Hu J, Zhang Z, Westerlind H, Bonfiglio F, Raj T, Torres J, Chen A, Petras R, Pardi DS, Iuga AC, Levi GS, Cao W, Jain P, Rieder F, Gordon IO, Cho JH, D'Amato M, Harpaz N, Hao K, Colombel JF, Peter I. Stahl E, et al. Gastroenterology. 2020 Aug;159(2):549-561.e8. doi: 10.1053/j.gastro.2020.04.063. Epub 2020 May 1. Gastroenterology. 2020. PMID: 32371109 Free PMC article.
Matching genotype data on control samples and CD, UC, and celiac disease cases were provided by the respective consortia. A discovery association study followed by meta-analysis with an independent cohort, polygenic risk score calculation, and cross-phenot …
Matching genotype data on control samples and CD, UC, and celiac disease cases were provided by the respective consortia. A discovery …
FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.
Yan T, Liang J, Gao J, Wang L, Fujioka H; Alzheimer Disease Neuroimaging Initiative; Zhu X, Wang X. Yan T, et al. Nat Commun. 2020 Jan 21;11(1):411. doi: 10.1038/s41467-019-13962-0. Nat Commun. 2020. PMID: 31964863 Free PMC article.
Alzheimer's disease (AD) is characterized by amyloid plaques and progressive cerebral atrophy. Here, we report FAM222A as a putative brain atrophy susceptibility gene. Our cross-phenotype association analysis of imaging genetics indicates …
Alzheimer's disease (AD) is characterized by amyloid plaques and progressive cerebral atrophy. Here, we report FAM222A …
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V, Cousminer DL, Dastani Z, Drong AW, Esko T, Evans DM, Falchi M, Feitosa MF, Ferreira T, Hedman ÅK, Haring R, Hysi PG, Iles MM, Justice AE, Kanoni S, Lagou V, Li R, Li X, Locke A, Lu C, Mägi R, Perry JR, Pers TH, Qi Q, Sanna M, Schmidt EM, Scott WR, Shungin D, Teumer A, Vinkhuyzen AA, Walker RW, Westra HJ, Zhang M, Zhang W, Zhao JH, Zhu Z, Afzal U, Ahluwalia TS, Bakker SJ, Bellis C, Bonnefond A, Borodulin K, Buchman AS, Cederholm T, Choh AC, Choi HJ, Curran JE, de Groot LC, De Jager PL, Dhonukshe-Rutten RA, Enneman AW, Eury E, Evans DS, Forsen T, Friedrich N, Fumeron F, Garcia ME, Gärtner S, Han BG, Havulinna AS, Hayward C, Hernandez D, Hillege H, Ittermann T, Kent JW, Kolcic I, Laatikainen T, Lahti J, Mateo Leach I, Lee CG, Lee JY, Liu T, Liu Y, Lobbens S, Loh M, Lyytikäinen LP, Medina-Gomez C, Michaëlsson K, Nalls MA, Nielson CM, Oozageer L, Pascoe L, Paternoster L, Polašek O, Ripatti S, Sarzynski MA, Shin CS, Narančić NS, Spira D, Srikanth P, Steinhagen-Thiessen E, Sung YJ, Swart KM, Taittonen L, Tanaka T, Tikkanen E, van der Velde N, van Schoor NM, Verweij N, Wright AF, Yu L, Zmuda JM, Eklund N, Forrester T, Grarup N, … See abstract for full author list ➔ Lu Y, et al. Nat Commun. 2016 Feb 1;7:10495. doi: 10.1038/ncomms10495. Nat Commun. 2016. PMID: 26833246 Free PMC article.
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. ...In particular, the loci more strongly …
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome- …
Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury.
Polimanti R, Chen CY, Ursano RJ, Heeringa SG, Jain S, Kessler RC, Nock MK, Smoller JW, Sun X, Gelernter J, Stein MB. Polimanti R, et al. J Neurotrauma. 2017 Feb 15;34(4):781-789. doi: 10.1089/neu.2016.4550. Epub 2016 Aug 25. J Neurotrauma. 2017. PMID: 27439997 Free PMC article.
Traumatic brain injury (TBI) contributes to the increased rates of suicide and post-traumatic stress disorder in military personnel and veterans, and it is also associated with the risk for neurodegenerative and psychiatric disorders. A cross-phenotype high-r …
Traumatic brain injury (TBI) contributes to the increased rates of suicide and post-traumatic stress disorder in military personnel and vete …
Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.
Gao XR, Huang H, Kim H. Gao XR, et al. Hum Mol Genet. 2019 Apr 1;28(7):1162-1172. doi: 10.1093/hmg/ddy422. Hum Mol Genet. 2019. PMID: 30535121 Free PMC article.
Other hits included many previously reported AMD genes, such as NPLOC4 (P = 1.7 10-103), RAD51B (P = 9.1 10-14) and SLC16A8 (P = 1.7 10-8), further providing functional significance of the identified loci. Through cross-phenotype analysis, these genetic loci also ex …
Other hits included many previously reported AMD genes, such as NPLOC4 (P = 1.7 10-103), RAD51B (P = 9.1 10-14) and SLC16A8 (P = 1.7 10-8), …
11 results