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504 results

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Page 1
Crotoxin Modulates Macrophage Phenotypic Reprogramming.
Neves CL, Barbosa CMV, Ranéia-Silva PA, Faquim-Mauro EL, Sampaio SC. Neves CL, et al. Toxins (Basel). 2023 Oct 17;15(10):616. doi: 10.3390/toxins15100616. Toxins (Basel). 2023. PMID: 37888647 Free PMC article.
Macrophage plasticity is a fundamental feature of the immune response since it favors the rapid and adequate change of the functional phenotype in response to the pathogen or the microenvironment. Several studies have shown that Crotoxin (CTX), the major toxin of the Crota …
Macrophage plasticity is a fundamental feature of the immune response since it favors the rapid and adequate change of the functional phenot …
Crotoxin: novel activities for a classic beta-neurotoxin.
Sampaio SC, Hyslop S, Fontes MR, Prado-Franceschi J, Zambelli VO, Magro AJ, Brigatte P, Gutierrez VP, Cury Y. Sampaio SC, et al. Toxicon. 2010 Jun 1;55(6):1045-60. doi: 10.1016/j.toxicon.2010.01.011. Epub 2010 Jan 28. Toxicon. 2010. PMID: 20109480 Free article. Review.
Crotoxin, the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, was the first snake venom protein to be purified and crystallized. ...The classic biological activities normally attributed to crotoxin include neurotoxicity, myotoxicity, n …
Crotoxin, the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, was the first snake venom protein to be …
Crotoxin, half-century of investigations on a phospholipase A2 neurotoxin.
Bon C, Bouchier C, Choumet V, Faure G, Jiang MS, Lambezat MP, Radvanyi F, Saliou B. Bon C, et al. Acta Physiol Pharmacol Latinoam. 1989;39(4):439-48. Acta Physiol Pharmacol Latinoam. 1989. PMID: 2562459 Review.
Binding experiments showed that crotoxin subunits dissociate when crotoxin interacts with biological membranes: Component-B binds, whereas component-A appears free in solution. ...Finally, immunochemical investigations carried out with polyclonal antibodies prepared …
Binding experiments showed that crotoxin subunits dissociate when crotoxin interacts with biological membranes: Component-B bi …
Cytotoxic effect of crotoxin on cancer cells and its antitumoral effects correlated to tumor microenvironment: A review.
Almeida TC, Ribeiro Silva LM, Boaventura de Oliveira AM, Lopes FSR, Sant'Anna MB, Picolo G. Almeida TC, et al. Int J Biol Macromol. 2023 Jul 1;242(Pt 2):124892. doi: 10.1016/j.ijbiomac.2023.124892. Epub 2023 May 15. Int J Biol Macromol. 2023. PMID: 37196721 Review.
Crotoxin also modulates tumor-associated fibroblasts, endothelial cells, and immune cells, which contribute to its antitumoral effects. In addition, preliminary clinical studies confirm the promising results of crotoxin and support its potential future use as an ant …
Crotoxin also modulates tumor-associated fibroblasts, endothelial cells, and immune cells, which contribute to its antitumoral effect …
Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties.
Sartim MA, Menaldo DL, Sampaio SV. Sartim MA, et al. J Venom Anim Toxins Incl Trop Dis. 2018 Dec 17;24:39. doi: 10.1186/s40409-018-0178-3. eCollection 2018. J Venom Anim Toxins Incl Trop Dis. 2018. PMID: 30564276 Free PMC article. Review.
For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus. ...Therefore, the present rev …
For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major …
Crotoxin B: Heterologous Expression, Protein Folding, Immunogenic Properties, and Irregular Presence in Crotalid Venoms.
Mejía-Sánchez MA, Clement H, Corrales-García LL, Olamendi-Portugal T, Carbajal A, Corzo G. Mejía-Sánchez MA, et al. Toxins (Basel). 2022 May 31;14(6):382. doi: 10.3390/toxins14060382. Toxins (Basel). 2022. PMID: 35737043 Free PMC article.
The secondary structure of HisrCrotoxin B was comparable to the secondary structure of the native Crotoxin B, and it has PLA(2) activity as the native Crotoxin B. HisrCrotoxin B was used to immunize rabbits, and the obtained antibodies partially inhibited the activi …
The secondary structure of HisrCrotoxin B was comparable to the secondary structure of the native Crotoxin B, and it has PLA(2) activ …
Crotoxin-Loaded Silica Nanoparticles: A Nanovenom Approach.
Conti FS, Giorgi E, Montaldo L, Rodríguez JP, De Marzi MC, Baudou FG. Conti FS, et al. Pharmaceutics. 2025 Jul 4;17(7):879. doi: 10.3390/pharmaceutics17070879. Pharmaceutics. 2025. PMID: 40733089 Free PMC article.
In Argentina, Crotalus durissus terrificus (C.d.t., South American rattlesnake) is one of the species of greatest medical importance since its venom contains mainly crotoxin (CTX), a potent enzyme-toxin with PLA(2) activity, which is responsible for its high lethality. ...
In Argentina, Crotalus durissus terrificus (C.d.t., South American rattlesnake) is one of the species of greatest medical importance since i …
Crotoxin promotes macrophage reprogramming towards an antiangiogenic phenotype.
de Araújo Pimenta L, de Almeida MES, Bretones ML, Cirillo MC, Curi R, Sampaio SC. de Araújo Pimenta L, et al. Sci Rep. 2019 Mar 12;9(1):4281. doi: 10.1038/s41598-019-40903-0. Sci Rep. 2019. PMID: 30862840 Free PMC article.
Crotoxin (CTX) is the primary toxin of South American rattlesnake Crotalus durissus terrificus venom. ...
Crotoxin (CTX) is the primary toxin of South American rattlesnake Crotalus durissus terrificus venom. ...
Crotoxin modulates inflammation and macrophages' functions in a murine sepsis model.
Bretones ML, Sampaio SC, Barbeiro DF, Ariga SKK, Soriano FG, Lima TM. Bretones ML, et al. Toxicon. 2022 Sep;216:132-138. doi: 10.1016/j.toxicon.2022.07.007. Epub 2022 Jul 16. Toxicon. 2022. PMID: 35850256 Free article.
It involves the early activation of inflammatory responses. Crotoxin (CTX), the major toxin of the South American rattlesnake Crotalus durissus terrificus venom, presents longstanding anti-inflammatory properties. ...
It involves the early activation of inflammatory responses. Crotoxin (CTX), the major toxin of the South American rattlesnake Crotalu …
Crotoxin Modulates Events Involved in Epithelial-Mesenchymal Transition in 3D Spheroid Model.
Kato EE, Sampaio SC. Kato EE, et al. Toxins (Basel). 2021 Nov 22;13(11):830. doi: 10.3390/toxins13110830. Toxins (Basel). 2021. PMID: 34822613 Free PMC article.
Several experimental (in vivo and in vitro) and clinical trial studies have shown the antitumor activity of crotoxin (CTX), a heterodimeric phospholipase A2 present in the Crotalus durissus terrificus venom. ...
Several experimental (in vivo and in vitro) and clinical trial studies have shown the antitumor activity of crotoxin (CTX), a heterod …
504 results