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Multiple myeloma biology: lessons from the 5TMM models.
Vanderkerken K, Asosingh K, Croucher P, Van Camp B. Vanderkerken K, et al. Among authors: croucher p. Immunol Rev. 2003 Aug;194:196-206. doi: 10.1034/j.1600-065x.2003.00035.x. Immunol Rev. 2003. PMID: 12846816 Review.
Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma.
McDonald MM, Reagan MR, Youlten SE, Mohanty ST, Seckinger A, Terry RL, Pettitt JA, Simic MK, Cheng TL, Morse A, Le LMT, Abi-Hanna D, Kramer I, Falank C, Fairfield H, Ghobrial IM, Baldock PA, Little DG, Kneissel M, Vanderkerken K, Bassett JHD, Williams GR, Oyajobi BO, Hose D, Phan TG, Croucher PI. McDonald MM, et al. Among authors: croucher pi. Blood. 2017 Jun 29;129(26):3452-3464. doi: 10.1182/blood-2017-03-773341. Epub 2017 May 17. Blood. 2017. PMID: 28515094 Free PMC article.
Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma.
Buckle CH, De Leenheer E, Lawson MA, Yong K, Rabin N, Perry M, Vanderkerken K, Croucher PI. Buckle CH, et al. Among authors: croucher pi. PLoS One. 2012;7(8):e41127. doi: 10.1371/journal.pone.0041127. Epub 2012 Aug 29. PLoS One. 2012. PMID: 22952578 Free PMC article.
C57BL/KaLwRij mice were injected with either 5T2MM or 5T33MM murine myeloma cells. 5T2MM-bearing mice developed osteolytic bone lesions (p<0.05) with increased osteoclast surface (p<0.01) and reduced trabecular bone volume (p<0.05). ...This was assoc …
C57BL/KaLwRij mice were injected with either 5T2MM or 5T33MM murine myeloma cells. 5T2MM-bearing mice developed osteolytic bone lesions ( …
Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: effect on myeloma bone disease in the 5T2MM murine model of myeloma.
Deleu S, Lemaire M, Arts J, Menu E, Van Valckenborgh E, Vande Broek I, De Raeve H, Coulton L, Van Camp B, Croucher P, Vanderkerken K. Deleu S, et al. Among authors: croucher p. Cancer Res. 2009 Jul 1;69(13):5307-11. doi: 10.1158/0008-5472.CAN-08-4472. Epub 2009 Jun 16. Cancer Res. 2009. PMID: 19531653
Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival.
Menu E, Jernberg-Wiklund H, De Raeve H, De Leenheer E, Coulton L, Gallagher O, Van Valckenborgh E, Larsson O, Axelson M, Nilsson K, Van Camp B, Croucher P, Vanderkerken K. Menu E, et al. Among authors: croucher p. Int J Cancer. 2007 Oct 15;121(8):1857-61. doi: 10.1002/ijc.22845. Int J Cancer. 2007. PMID: 17546599
Myeloma bone disease and proteasome inhibition therapies.
Terpos E, Sezer O, Croucher P, Dimopoulos MA. Terpos E, et al. Among authors: croucher p. Blood. 2007 Aug 15;110(4):1098-104. doi: 10.1182/blood-2007-03-067710. Epub 2007 May 9. Blood. 2007. PMID: 17494860 Review.
Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model.
Menu E, De Leenheer E, De Raeve H, Coulton L, Imanishi T, Miyashita K, Van Valckenborgh E, Van Riet I, Van Camp B, Horuk R, Croucher P, Vanderkerken K. Menu E, et al. Among authors: croucher p. Clin Exp Metastasis. 2006;23(5-6):291-300. doi: 10.1007/s10585-006-9038-6. Epub 2006 Nov 3. Clin Exp Metastasis. 2006. PMID: 17086356
The 5T2MM murine model of multiple myeloma: maintenance and analysis.
Vanderkerken K, Asosingh K, Willems A, De Raeve H, Couck P, Gorus F, Croucher P, Van Camp B. Vanderkerken K, et al. Among authors: croucher p. Methods Mol Med. 2005;113:191-205. doi: 10.1385/1-59259-916-8:191. Methods Mol Med. 2005. PMID: 15968104
Myeloma cells (5TMM) and their interactions with the marrow microenvironment.
Menu E, Asosingh K, Van Riet I, Croucher P, Van Camp B, Vanderkerken K. Menu E, et al. Among authors: croucher p. Blood Cells Mol Dis. 2004 Sep-Oct;33(2):111-9. doi: 10.1016/j.bcmd.2004.04.012. Blood Cells Mol Dis. 2004. PMID: 15315788 Review.
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