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Structural studies on bioactive compounds. 39. Biological consequences of the structural modification of DHFR-inhibitory 2,4-diamino-6-(4-substituted benzylamino-3-nitrophenyl)-6-ethylpyrimidines ('benzoprims').
J Med Chem. 2004 Jul 29;47(16):4105-8. doi: 10.1021/jm040785+.
J Med Chem. 2004.
PMID: 15267250
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G.
Bouwmeester T, et al. Among authors: croughton k.
Nat Cell Biol. 2004 Feb;6(2):97-105. doi: 10.1038/ncb1086. Epub 2004 Jan 25.
Nat Cell Biol. 2004.
PMID: 14743216
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Investigations on the biological properties of the lipophilic DHFR-inhibitory benzoprims reveal non-folate modes of action and opportunities for anti-cancer drug design.
Croughton KA, Matthews CS, Griffin RJ, Stevens MF.
Croughton KA, et al.
Anticancer Drug Des. 2001 Apr-Jun;16(2-3):119-28.
Anticancer Drug Des. 2001.
PMID: 11962509
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