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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice.
Johnson L, Mercer K, Greenbaum D, Bronson RT, Crowley D, Tuveson DA, Jacks T. Johnson L, et al. Nature. 2001 Apr 26;410(6832):1111-6. doi: 10.1038/35074129. Nature. 2001. PMID: 11323676
In vivo roles of integrins during leukocyte development and traffic: insights from the analysis of mice chimeric for alpha 5, alpha v, and alpha 4 integrins.
Arroyo AG, Taverna D, Whittaker CA, Strauch UG, Bader BL, Rayburn H, Crowley D, Parker CM, Hynes RO. Arroyo AG, et al. J Immunol. 2000 Oct 15;165(8):4667-75. doi: 10.4049/jimmunol.165.8.4667. J Immunol. 2000. PMID: 11035110
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.
Hodivala-Dilke KM, McHugh KP, Tsakiris DA, Rayburn H, Crowley D, Ullman-Culleré M, Ross FP, Coller BS, Teitelbaum S, Hynes RO. Hodivala-Dilke KM, et al. J Clin Invest. 1999 Jan;103(2):229-38. doi: 10.1172/JCI5487. J Clin Invest. 1999. PMID: 9916135 Free PMC article.
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors.
McClatchey AI, Saotome I, Mercer K, Crowley D, Gusella JF, Bronson RT, Jacks T. McClatchey AI, et al. Genes Dev. 1998 Apr 15;12(8):1121-33. doi: 10.1101/gad.12.8.1121. Genes Dev. 1998. PMID: 9553042 Free PMC article.
p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer.
McFadden DG, Vernon A, Santiago PM, Martinez-McFaline R, Bhutkar A, Crowley DM, McMahon M, Sadow PM, Jacks T. McFadden DG, et al. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1600-9. doi: 10.1073/pnas.1404357111. Epub 2014 Apr 7. Proc Natl Acad Sci U S A. 2014. PMID: 24711431 Free PMC article.
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