Crowther DC - Search Results

1

Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis.

Sharp LK, Mallya M, Kinghorn KJ, Wang Z, Crowther DC, Huntington JA, Belorgey D, Lomas DA. Sharp LK, et al. Among authors: crowther dc. FEBS J. 2006 Jun;273(11):2540-52. doi: 10.1111/j.1742-4658.2006.05262.x. FEBS J. 2006. PMID: 16704419 Free article.

2

Molecular mousetraps and the serpinopathies.

Lomas DA, Belorgey D, Mallya M, Miranda E, Kinghorn KJ, Sharp LK, Phillips RL, Page R, Robertson AS, Crowther DC. Lomas DA, et al. Among authors: crowther dc. Biochem Soc Trans. 2005 Apr;33(Pt 2):321-30. doi: 10.1042/BST0330321. Biochem Soc Trans. 2005. PMID: 15787598

3

Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro.

Belorgey D, Crowther DC, Mahadeva R, Lomas DA. Belorgey D, et al. Among authors: crowther dc. J Biol Chem. 2002 May 10;277(19):17367-73. doi: 10.1074/jbc.M200680200. Epub 2002 Mar 5. J Biol Chem. 2002. PMID: 11880376 Free article.

4

Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies.

Crowther DC, Belorgey D, Miranda E, Kinghorn KJ, Sharp LK, Lomas DA. Crowther DC, et al. Eur J Hum Genet. 2004 Mar;12(3):167-72. doi: 10.1038/sj.ejhg.5201127. Eur J Hum Genet. 2004. PMID: 14694355 Review.

5

Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB.

Belorgey D, Sharp LK, Crowther DC, Onda M, Johansson J, Lomas DA. Belorgey D, et al. Among authors: crowther dc. Eur J Biochem. 2004 Aug;271(16):3360-7. doi: 10.1111/j.1432-1033.2004.04270.x. Eur J Biochem. 2004. PMID: 15291813 Free article.

6

Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies.

Lomas DA, Belorgey D, Mallya M, Onda M, Kinghorn KJ, Sharp LK, Phillips RL, Page R, Crowther DC, Miranda E. Lomas DA, et al. Among authors: crowther dc. Front Biosci. 2004 Sep 1;9:2873-91. doi: 10.2741/1444. Front Biosci. 2004. PMID: 15353322 Review.

7

Unravelling the twists and turns of the serpinopathies.

Roussel BD, Irving JA, Ekeowa UI, Belorgey D, Haq I, Ordóñez A, Kruppa AJ, Duvoix A, Rashid ST, Crowther DC, Marciniak SJ, Lomas DA. Roussel BD, et al. Among authors: crowther dc. FEBS J. 2011 Oct;278(20):3859-67. doi: 10.1111/j.1742-4658.2011.08201.x. Epub 2011 Jun 20. FEBS J. 2011. PMID: 21624056 Free article. Review.

8

Nucleation of alpha 1-antichymotrypsin polymerization.

Crowther DC, Serpell LC, Dafforn TR, Gooptu B, Lomas DA. Crowther DC, et al. Biochemistry. 2003 Mar 4;42(8):2355-63. doi: 10.1021/bi0259305. Biochemistry. 2003. PMID: 12600202

9

Therapeutic targets from a Drosophila model of Alzheimer's disease.

Crowther DC, Kinghorn KJ, Page R, Lomas DA. Crowther DC, et al. Curr Opin Pharmacol. 2004 Oct;4(5):513-6. doi: 10.1016/j.coph.2004.07.001. Curr Opin Pharmacol. 2004. PMID: 15351357 Review.

10

Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.

Kinghorn KJ, Crowther DC, Sharp LK, Nerelius C, Davis RL, Chang HT, Green C, Gubb DC, Johansson J, Lomas DA. Kinghorn KJ, et al. Among authors: crowther dc. J Biol Chem. 2006 Sep 29;281(39):29268-77. doi: 10.1074/jbc.M600690200. Epub 2006 Jul 17. J Biol Chem. 2006. PMID: 16849336 Free article.

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