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Gene replacement in parasitic protozoa.
Cruz A, Beverley SM. Cruz A, et al. Nature. 1990 Nov 8;348(6297):171-3. doi: 10.1038/348171a0. Nature. 1990. PMID: 2234081
Many molecules likely to have a role during the infectious cycle have been identified, yet proof of their function is often lacking. We describe studies in Leishmania major of homologous gene targeting, a powerful method for testing gene function in other organisms. …
Many molecules likely to have a role during the infectious cycle have been identified, yet proof of their function is often lacking. …
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.
Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Apicco DJ, et al. Nat Neurosci. 2018 Jan;21(1):72-80. doi: 10.1038/s41593-017-0022-z. Epub 2017 Nov 20. Nat Neurosci. 2018. PMID: 29273772 Free PMC article.
These data provide in vivo evidence that TIA1 plays a key role in mediating toxicity and further suggest that RBPs direct the pathway of tau aggregation and the resulting neurodegeneration. We propose a model in which dysfunction of the translational stress response …
These data provide in vivo evidence that TIA1 plays a key role in mediating toxicity and further suggest that RBPs direct the pathway …
Thymidine kinase as a negative selectable marker in Leishmania major.
LeBowitz JH, Cruz A, Beverley SM. LeBowitz JH, et al. Mol Biochem Parasitol. 1992 Apr;51(2):321-5. doi: 10.1016/0166-6851(92)90082-u. Mol Biochem Parasitol. 1992. PMID: 1315415 No abstract available.
Double targeted gene replacement for creating null mutants.
Cruz A, Coburn CM, Beverley SM. Cruz A, et al. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7170-4. doi: 10.1073/pnas.88.16.7170. Proc Natl Acad Sci U S A. 1991. PMID: 1651496 Free PMC article.
We developed an improved hygromycin B-resistance cassette encoding hygromycin phosphotransferase (HYG) for use as a selectable marker for Leishmania. ...A HYG targeting vector was utilized to replace the single dihydrofolate reductase-thymidylate synthase (DHFR-TS) …
We developed an improved hygromycin B-resistance cassette encoding hygromycin phosphotransferase (HYG) for use as a selectable marker …
A therapeutic target for hormone-independent estrogen receptor-positive breast cancers.
Biswas DK, Cruz A, Pettit N, Mutter GL, Pardee AB. Biswas DK, et al. Mol Med. 2001 Jan;7(1):59-67. Mol Med. 2001. PMID: 11474128 Free PMC article.
BACKGROUND: The action of the steroid hormone estradiol (E2) is mediated via interaction with a specific receptor (ER) that initiates a series of events downstream, leading to the modulation of hormone-responsive genes and cell proliferation. ...ER-ERE complex forma …
BACKGROUND: The action of the steroid hormone estradiol (E2) is mediated via interaction with a specific receptor (ER) that initiates …
The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers.
Biswas DK, Dai SC, Cruz A, Weiser B, Graner E, Pardee AB. Biswas DK, et al. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10386-91. doi: 10.1073/pnas.151257998. Epub 2001 Aug 21. Proc Natl Acad Sci U S A. 2001. PMID: 11517301 Free PMC article.
The effect of a kinase inhibitor Go6796 on growth of epidermal growth factor (EGF)-stimulated estrogen receptor negative (ER-) breast cancer cells in vivo and role of nuclear factor kappa B (NF-kappaB) on tumorogenesis have been investigated. ...Thus, NF-kappaB is a
The effect of a kinase inhibitor Go6796 on growth of epidermal growth factor (EGF)-stimulated estrogen receptor negative (ER-) breast …
The implementation of an integrated information system for substance use screening in general medical settings.
Shanahan CW, Sorensen-Alawad A, Carney BL, Persand I, Cruz A, Botticelli M, Pressman K, Adams WG, Brolin M, Alford DP. Shanahan CW, et al. Appl Clin Inform. 2014 Oct 22;5(4):878-94. doi: 10.4338/ACI-2014-03-RA-0025. eCollection 2014. Appl Clin Inform. 2014. PMID: 25589904 Free PMC article.
The Massachusetts Screening, Brief Intervention and Referral to Treatment (MASBIRT) Program, a substance use screening program in general medical settings, created a web-based, point-of-care (POC), application--the MASBIRT Portal (the "Portal") to meet program goals …
The Massachusetts Screening, Brief Intervention and Referral to Treatment (MASBIRT) Program, a substance use screening program in gen …
Tar Spot: An Understudied Disease Threatening Corn Production in the Americas.
Valle-Torres J, Ross TJ, Plewa D, Avellaneda MC, Check J, Chilvers MI, Cruz AP, Dalla Lana F, Groves C, Gongora-Canul C, Henriquez-Dole L, Jamann T, Kleczewski N, Lipps S, Malvick D, McCoy AG, Mueller DS, Paul PA, Puerto C, Schloemer C, Raid RN, Robertson A, Roggenkamp EM, Smith DL, Telenko DEP, Cruz CD. Valle-Torres J, et al. Among authors: cruz ap. Plant Dis. 2020 Aug 7:PDIS02200449FE. doi: 10.1094/PDIS-02-20-0449-FE. Online ahead of print. Plant Dis. 2020. PMID: 32762502
Cabbage and fermented vegetables: from death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19.
Bousquet J, Anto JM, Czarlewski W, Haahtela T, Fonseca SC, Iaccarino G, Blain H, Vidal A, Sheikh A, Akdis CA, Zuberbier T; ARIA group. Bousquet J, et al. Allergy. 2020 Aug 6. doi: 10.1111/all.14549. Online ahead of print. Allergy. 2020. PMID: 32762135 Review.
The plausible role of Deep Cervical Fascia and its continuum in chronic craniofacial and Cervicobrachial Pain: A case report.
Raja G P, Fernandes S, Cruz AM, Prabhu A. Raja G P, et al. Among authors: cruz am. Heliyon. 2020 Jul 27;6(7):e04560. doi: 10.1016/j.heliyon.2020.e04560. eCollection 2020 Jul. Heliyon. 2020. PMID: 32760842 Free PMC article.
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