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X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis.
Haslinger K, Peschke M, Brieke C, Maximowitsch E, Cryle MJ. Haslinger K, et al. Among authors: cryle mj. Nature. 2015 May 7;521(7550):105-9. doi: 10.1038/nature14141. Epub 2015 Feb 9. Nature. 2015. PMID: 25686610
Crystal structures of substrate-free and retinoic acid-bound cyanobacterial cytochrome P450 CYP120A1.
Kühnel K, Ke N, Cryle MJ, Sligar SG, Schuler MA, Schlichting I. Kühnel K, et al. Among authors: cryle mj. Biochemistry. 2008 Jun 24;47(25):6552-9. doi: 10.1021/bi800328s. Biochemistry. 2008. PMID: 18512957
Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Cryle MJ, Schlichting I. Cryle MJ, et al. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15696-701. doi: 10.1073/pnas.0805983105. Epub 2008 Oct 6. Proc Natl Acad Sci U S A. 2008. PMID: 18838690 Free PMC article.
Structural characterization of OxyD, a cytochrome P450 involved in beta-hydroxytyrosine formation in vancomycin biosynthesis.
Cryle MJ, Meinhart A, Schlichting I. Cryle MJ, et al. J Biol Chem. 2010 Aug 6;285(32):24562-74. doi: 10.1074/jbc.M110.131904. Epub 2010 Jun 1. J Biol Chem. 2010. PMID: 20519494 Free PMC article.
Selectivity in a barren landscape: the P450(BioI)-ACP complex.
Cryle MJ. Cryle MJ. Biochem Soc Trans. 2010 Aug;38(4):934-9. doi: 10.1042/BST0380934. Biochem Soc Trans. 2010. PMID: 20658980 Review.
Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Cryle MJ, Bell SG, Schlichting I. Cryle MJ, et al. Biochemistry. 2010 Aug 31;49(34):7282-96. doi: 10.1021/bi100910y. Biochemistry. 2010. PMID: 20690619
Structural characterization of CYP165D3, a cytochrome P450 involved in phenolic coupling in teicoplanin biosynthesis.
Cryle MJ, Staaden J, Schlichting I. Cryle MJ, et al. Arch Biochem Biophys. 2011 Mar 1;507(1):163-73. doi: 10.1016/ Epub 2010 Oct 23. Arch Biochem Biophys. 2011. PMID: 20974107
Carrier protein substrates in cytochrome P450-catalysed oxidation.
Cryle MJ. Cryle MJ. Metallomics. 2011 Apr;3(4):323-6. doi: 10.1039/c0mt00081g. Epub 2011 Jan 18. Metallomics. 2011. PMID: 21243168 Review.
Cytochrome p450sky interacts directly with the nonribosomal peptide synthetase to generate three amino acid precursors in skyllamycin biosynthesis.
Uhlmann S, Süssmuth RD, Cryle MJ. Uhlmann S, et al. Among authors: cryle mj. ACS Chem Biol. 2013 Nov 15;8(11):2586-96. doi: 10.1021/cb400555e. Epub 2013 Sep 30. ACS Chem Biol. 2013. PMID: 24079328
A facile Fmoc solid phase synthesis strategy to access epimerization-prone biosynthetic intermediates of glycopeptide antibiotics.
Brieke C, Cryle MJ. Brieke C, et al. Among authors: cryle mj. Org Lett. 2014 May 2;16(9):2454-7. doi: 10.1021/ol500840f. Epub 2014 Apr 14. Org Lett. 2014. PMID: 24730694
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