Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular design.
Science. 2010.
PMID: 20947757
Free PMC article.
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Disrupting Crystal Growth through Molecular Recognition: Designer Therapies for Kidney Stone Prevention.
Acc Chem Res. 2022 Feb 15;55(4):516-525. doi: 10.1021/acs.accounts.1c00631. Epub 2022 Jan 28.
Acc Chem Res. 2022.
PMID: 35088591
Free PMC article.
Despite this long history, however, a fundamental understanding of the stages of stone formation and the rational design of therapies for stone prevention have remained elusive.This Account reviews discoveries and advances from our laboratories that have unraveled t …
Despite this long history, however, a fundamental understanding of the stages of stone formation and the rational design of therapies …
Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular design.
Science. 2010 Oct 15;330(6002):337-341. doi: 10.1126/science.1191968.
Science. 2010.
PMID: 20947757
Free PMC article.
Crystallization of L-cystine is a critical step in the pathogenesis of cystine kidney stones. ...The AFM observations are mirrored by reduced crystal yield and crystal size in the presence of L-CDME and L-CME, collectively s …
Crystallization of L-cystine is a critical step in the pathogenesis of cystine kidney stones. ...T …
Cystine growth inhibition through molecular mimicry: a new paradigm for the prevention of crystal diseases.
Curr Rheumatol Rep. 2015 May;17(5):33. doi: 10.1007/s11926-015-0510-7.
Curr Rheumatol Rep. 2015.
PMID: 25874348
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Review.
Recently, we employed atomic force miscopy (AFM) to identify L-cystine dimethylester (CDME) as an effective molecular imposter of L-cystine, capable of inhibiting crystal growth in vitro. More recently, we demonstrated CDME's effic …
Recently, we employed atomic force miscopy (AFM) to identify L-cystine dimethylester (CDME) as an effective molecular i …
Role of Molecular Recognition in l-Cystine Crystal Growth Inhibition.
Cryst Growth Des. 2017 May 3;17(5):2767-2781. doi: 10.1021/acs.cgd.7b00236. Epub 2017 Apr 13.
Cryst Growth Des. 2017.
PMID: 29234242
Free PMC article.
l-Cystine kidney stones-aggregates of single crystals of the hexagonal form of l-cystine-afflict more than 20 000 individuals in the United States alone. ...Collectively, these findings identify the key structural factors responsible for …
l-Cystine kidney stones-aggregates of single crystals of the hexagonal form of l-cystine-afflict m …
Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria.
Bioorg Med Chem Lett. 2018 May 1;28(8):1303-1308. doi: 10.1016/j.bmcl.2018.03.024. Epub 2018 Mar 10.
Bioorg Med Chem Lett. 2018.
PMID: 29571572
Free PMC article.
To overcome the chemical and metabolic stability issues of l-cystine dimethyl ester (CDME) and l-cystine methyl ester (CME), a series of l-cystine diamides with or without N(alpha)-methylation was designed, synthesized, and evaluat …
To overcome the chemical and metabolic stability issues of l-cystine dimethyl ester (CDME) and l-cystine methyl …
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