Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 1
2001 1
2002 2
2003 1
2006 1
2007 1
2008 1
2010 1
2011 1
2018 4
2019 1
2023 1
2024 1
2025 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

17 results

Results by year

Filters applied: . Clear all
Page 1
Hexameric architecture of CstF supported by CstF-50 homodimerization domain structure.
Moreno-Morcillo M, Minvielle-Sébastia L, Mackereth C, Fribourg S. Moreno-Morcillo M, et al. RNA. 2011 Mar;17(3):412-8. doi: 10.1261/rna.2481011. Epub 2011 Jan 13. RNA. 2011. PMID: 21233223 Free PMC article.
Here, we describe the crystal structure of the N-terminal domain of Drosophila CstF-50 subunit. It forms a compact homodimer that exposes two geometrically opposite, identical, and conserved surfaces that may serve as binding platform. Together with previous data on …
Here, we describe the crystal structure of the N-terminal domain of Drosophila CstF-50 subunit. It forms a compact homodimer t …
Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3'-end processing signals.
Yang W, Hsu PL, Yang F, Song JE, Varani G. Yang W, et al. Nucleic Acids Res. 2018 Jan 25;46(2):493-503. doi: 10.1093/nar/gkx1177. Nucleic Acids Res. 2018. PMID: 29186539 Free PMC article.
In this study, we provide a structural basis for the recruitment of CstF-50 to CstF via interaction with CstF-77 and establish that the hexameric assembly of CstF creates a high affinity platform to target various G/U-rich sequences. We further demonstrate that CstF …
In this study, we provide a structural basis for the recruitment of CstF-50 to CstF via interaction with CstF-77 and establish …
The structural basis of CstF-77 modulation of cleavage and polyadenylation through stimulation of CstF-64 activity.
Grozdanov PN, Masoumzadeh E, Latham MP, MacDonald CC. Grozdanov PN, et al. Nucleic Acids Res. 2018 Dec 14;46(22):12022-12039. doi: 10.1093/nar/gky862. Nucleic Acids Res. 2018. PMID: 30257008 Free PMC article.
Less is known about the function of the other two subunits of CstF, CstF-77 and CstF-50. Here, we show that the carboxy-terminus of CstF-77 plays a previously unrecognized role in enhancing C/P by altering how the RNA recognition motif (RRM) of CstF-64 binds RNA. .. …
Less is known about the function of the other two subunits of CstF, CstF-77 and CstF-50. Here, we show that the carboxy-termin …
mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response.
Fonseca D, Baquero J, Murphy MR, Aruggoda G, Varriano S, Sapienza C, Mashadova O, Rahman S, Kleiman FE. Fonseca D, et al. Mol Cell Biol. 2018 Jan 29;38(4):e00364-17. doi: 10.1128/MCB.00364-17. Print 2018 Feb 15. Mol Cell Biol. 2018. PMID: 29180510 Free PMC article.
CstF-50 and p97 formed complexes with BRCA1/BARD1, Ub, and some BRCA1/BARD1 substrates, such as RNA polymerase (RNAP) II and histones. Furthermore, CstF-50 and p97 had an additive effect on the activation of the ubiquitination of these BRCA1/BARD1 subs
CstF-50 and p97 formed complexes with BRCA1/BARD1, Ub, and some BRCA1/BARD1 substrates, such as RNA polymerase (RNAP) II and h
The structure of the CstF-77 homodimer provides insights into CstF assembly.
Legrand P, Pinaud N, Minvielle-Sébastia L, Fribourg S. Legrand P, et al. Nucleic Acids Res. 2007;35(13):4515-22. doi: 10.1093/nar/gkm458. Epub 2007 Jun 21. Nucleic Acids Res. 2007. PMID: 17584787 Free PMC article.
This heterotrimeric complex is built around the 77-kDa protein bridging both CstF-64 and CstF-50 subunits. We have solved the crystal structure of the 77-kDa protein from Encephalitozoon cuniculi at a resolution of 2 A. ...
This heterotrimeric complex is built around the 77-kDa protein bridging both CstF-64 and CstF-50 subunits. We have solved the …
BRCA1-dependent and independent functions of BARD1.
Irminger-Finger I, Leung WC. Irminger-Finger I, et al. Int J Biochem Cell Biol. 2002 Jun;34(6):582-7. doi: 10.1016/s1357-2725(01)00161-3. Int J Biochem Cell Biol. 2002. PMID: 11943588 Review.
A potential role of BARD1-BRCA1 complexes in ubiquitination of RNA Pol II, and the interaction of BARD1 with polyadenylation factor CstF-50, thus inhibiting mRNA processing, provide mechanisms for tumor suppression. BRCA1-independent functions of BARD1 were first no …
A potential role of BARD1-BRCA1 complexes in ubiquitination of RNA Pol II, and the interaction of BARD1 with polyadenylation factor CstF
Cstf2t Regulates expression of histones and histone-like proteins in male germ cells.
Grozdanov PN, Li J, Yu P, Yan W, MacDonald CC. Grozdanov PN, et al. Andrology. 2018 Jul;6(4):605-615. doi: 10.1111/andr.12488. Epub 2018 Apr 19. Andrology. 2018. PMID: 29673127 Free PMC article.
The cleavage stimulation factor (CstF) has three subunits, CstF-50 (gene symbol Cstf1), CstF-64 (Cstf2), and CstF-77 (Cstf3). Of these, CstF-64 is the RNA-binding subunit that interacts with the pre-mRNA downstream of the cleavage site. ...
The cleavage stimulation factor (CstF) has three subunits, CstF-50 (gene symbol Cstf1), CstF-64 (Cstf2), and CstF-77 (Cstf3). …
Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.
Kleiman FE, Manley JL. Kleiman FE, et al. Science. 1999 Sep 3;285(5433):1576-9. doi: 10.1126/science.285.5433.1576. Science. 1999. PMID: 10477523
Polyadenylation of messenger RNA precursors requires a complex protein machinery that is closely integrated with the even more complex transcriptional apparatus. Here a polyadenylation factor, CstF-50 (cleavage stimulation factor), is shown to interact in vitro and …
Polyadenylation of messenger RNA precursors requires a complex protein machinery that is closely integrated with the even more complex trans …
The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.
Edwards RA, Lee MS, Tsutakawa SE, Williams RS, Nazeer I, Kleiman FE, Tainer JA, Glover JN. Edwards RA, et al. Biochemistry. 2008 Nov 4;47(44):11446-56. doi: 10.1021/bi801115g. Epub 2008 Oct 9. Biochemistry. 2008. PMID: 18842000 Free PMC article.
The BARD1 N-terminal RING domain binds BRCA1 while the BARD1 C-terminal ankyrin and tandem BRCT repeat domains bind CstF-50 to modulate mRNA processing and RNAP II stability in response to DNA damage. Here we characterize the BARD1 structural biochemistry responsibl …
The BARD1 N-terminal RING domain binds BRCA1 while the BARD1 C-terminal ankyrin and tandem BRCT repeat domains bind CstF-50 to …
17 results