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The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease.
Cuadrado A, Moreno-Murciano P, Pedraza-Chaverri J. Cuadrado A, et al. Expert Opin Ther Targets. 2009 Mar;13(3):319-29. doi: 10.1517/13543780802716501. Expert Opin Ther Targets. 2009. PMID: 19236154 Review.
Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals.
Salinas M, Martín D, Alvarez A, Cuadrado A. Salinas M, et al. Among authors: cuadrado a. Mol Cell Neurosci. 2001 Jan;17(1):67-77. doi: 10.1006/mcne.2000.0921. Mol Cell Neurosci. 2001. PMID: 11161470
Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.
Martin D, Salinas M, Fujita N, Tsuruo T, Cuadrado A. Martin D, et al. Among authors: cuadrado a. J Biol Chem. 2002 Nov 8;277(45):42943-52. doi: 10.1074/jbc.M201070200. Epub 2002 Sep 3. J Biol Chem. 2002. PMID: 12213802
Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner.
Salinas M, Diaz R, Abraham NG, Ruiz de Galarreta CM, Cuadrado A. Salinas M, et al. Among authors: cuadrado a. J Biol Chem. 2003 Apr 18;278(16):13898-904. doi: 10.1074/jbc.M209164200. Epub 2003 Feb 10. J Biol Chem. 2003. PMID: 12578834
Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol.
Martin D, Rojo AI, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta CM, Cuadrado A. Martin D, et al. Among authors: cuadrado a. J Biol Chem. 2004 Mar 5;279(10):8919-29. doi: 10.1074/jbc.M309660200. Epub 2003 Dec 19. J Biol Chem. 2004. PMID: 14688281
Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB.
Rojo AI, Salinas M, Martín D, Perona R, Cuadrado A. Rojo AI, et al. Among authors: cuadrado a. J Neurosci. 2004 Aug 18;24(33):7324-34. doi: 10.1523/JNEUROSCI.2111-04.2004. J Neurosci. 2004. PMID: 15317858 Free PMC article.
Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo.
Salinas M, Wang J, Rosa de Sagarra M, Martín D, Rojo AI, Martin-Perez J, Ortiz de Montellano PR, Cuadrado A. Salinas M, et al. Among authors: cuadrado a. FEBS Lett. 2004 Dec 3;578(1-2):90-4. doi: 10.1016/j.febslet.2004.10.077. FEBS Lett. 2004. PMID: 15581622
Inhibition of heme oxygenase-1 interferes with the transforming activity of the Kaposi sarcoma herpesvirus-encoded G protein-coupled receptor.
Marinissen MJ, Tanos T, Bolós M, de Sagarra MR, Coso OA, Cuadrado A. Marinissen MJ, et al. Among authors: cuadrado a. J Biol Chem. 2006 Apr 21;281(16):11332-46. doi: 10.1074/jbc.M512199200. Epub 2006 Feb 13. J Biol Chem. 2006. PMID: 16476737
Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation.
González-Santiago L, Suárez Y, Zarich N, Muñoz-Alonso MJ, Cuadrado A, Martínez T, Goya L, Iradi A, Sáez-Tormo G, Maier JV, Moorthy A, Cato AC, Rojas JM, Muñoz A. González-Santiago L, et al. Among authors: cuadrado a. Cell Death Differ. 2006 Nov;13(11):1968-81. doi: 10.1038/sj.cdd.4401898. Epub 2006 Mar 17. Cell Death Differ. 2006. PMID: 16543941
Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.
Salazar M, Rojo AI, Velasco D, de Sagarra RM, Cuadrado A. Salazar M, et al. Among authors: cuadrado a. J Biol Chem. 2006 May 26;281(21):14841-51. doi: 10.1074/jbc.M513737200. Epub 2006 Mar 21. J Biol Chem. 2006. PMID: 16551619
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