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15 results
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Development of in silico models for human liver microsomal stability.
Lee PH, Cucurull-Sanchez L, Lu J, Du YJ. Lee PH, et al. J Comput Aided Mol Des. 2007 Dec;21(12):665-73. doi: 10.1007/s10822-007-9124-0. Epub 2007 Jun 29. J Comput Aided Mol Des. 2007. PMID: 17599241
Successful identification of key chemical structure modifications that lead to improved ADME profiles.
Cucurull-Sanchez L. Cucurull-Sanchez L. J Comput Aided Mol Des. 2010 May;24(5):449-58. doi: 10.1007/s10822-010-9361-5. Epub 2010 May 9. J Comput Aided Mol Des. 2010. PMID: 20455006
Structural pairwise comparisons of HLM stability of phenyl derivatives: Introduction of the Pfizer metabolism index (PMI) and metabolism-lipophilicity efficiency (MLE).
Lewis ML, Cucurull-Sanchez L. Lewis ML, et al. J Comput Aided Mol Des. 2009 Feb;23(2):97-103. doi: 10.1007/s10822-008-9242-3. Epub 2008 Sep 18. J Comput Aided Mol Des. 2009. PMID: 18802667
Relevance of systems pharmacology in drug discovery.
Cucurull-Sanchez L, Spink KG, Moschos SA. Cucurull-Sanchez L, et al. Drug Discov Today. 2012 Jul;17(13-14):665-70. doi: 10.1016/j.drudis.2012.01.015. Epub 2012 Jan 25. Drug Discov Today. 2012. PMID: 22405899
ADME SARfari: comparative genomics of drug metabolizing systems.
Davies M, Dedman N, Hersey A, Papadatos G, Hall MD, Cucurull-Sanchez L, Jeffrey P, Hasan S, Eddershaw PJ, Overington JP. Davies M, et al. Among authors: cucurull sanchez l. Bioinformatics. 2015 May 15;31(10):1695-7. doi: 10.1093/bioinformatics/btv010. Epub 2015 Jan 8. Bioinformatics. 2015. PMID: 25964657 Free PMC article.
Reducing systems biology to practice in pharmaceutical company research; selected case studies.
Benson N, Cucurull-Sanchez L, Demin O, Smirnov S, van der Graaf P. Benson N, et al. Among authors: cucurull sanchez l. Adv Exp Med Biol. 2012;736:607-15. doi: 10.1007/978-1-4419-7210-1_36. Adv Exp Med Biol. 2012. PMID: 22161355
The promises of quantitative systems pharmacology modelling for drug development.
Knight-Schrijver VR, Chelliah V, Cucurull-Sanchez L, Le Novère N. Knight-Schrijver VR, et al. Among authors: cucurull sanchez l. Comput Struct Biotechnol J. 2016 Sep 23;14:363-370. doi: 10.1016/j.csbj.2016.09.002. eCollection 2016. Comput Struct Biotechnol J. 2016. PMID: 27761201 Free PMC article. Review.
Agent-Based Modeling in Systems Pharmacology.
Cosgrove J, Butler J, Alden K, Read M, Kumar V, Cucurull-Sanchez L, Timmis J, Coles M. Cosgrove J, et al. Among authors: cucurull sanchez l. CPT Pharmacometrics Syst Pharmacol. 2015 Nov;4(11):615-29. doi: 10.1002/psp4.12018. Epub 2015 Nov 13. CPT Pharmacometrics Syst Pharmacol. 2015. PMID: 26783498 Free PMC article.
Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network.
Cucurull-Sanchez L, Chappell MJ, Chelliah V, Amy Cheung SY, Derks G, Penney M, Phipps A, Malik-Sheriff RS, Timmis J, Tindall MJ, van der Graaf PH, Vicini P, Yates JWT. Cucurull-Sanchez L, et al. CPT Pharmacometrics Syst Pharmacol. 2019 May;8(5):259-272. doi: 10.1002/psp4.12381. Epub 2019 Mar 22. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30667172 Free PMC article.
ASPASIA: A toolkit for evaluating the effects of biological interventions on SBML model behaviour.
Evans S, Alden K, Cucurull-Sanchez L, Larminie C, Coles MC, Kullberg MC, Timmis J. Evans S, et al. Among authors: cucurull sanchez l. PLoS Comput Biol. 2017 Feb 3;13(2):e1005351. doi: 10.1371/journal.pcbi.1005351. eCollection 2017 Feb. PLoS Comput Biol. 2017. PMID: 28158307 Free PMC article.
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