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Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity.
Conley RK, Cumberbatch MJ, Mason GS, Williamson DJ, Harrison T, Locker K, Swain C, Maubach K, O'Donnell R, Rigby M, Hewson L, Smith D, Rupniak NM. Conley RK, et al. Among authors: cumberbatch mj. J Neurosci. 2002 Sep 1;22(17):7730-6. doi: 10.1523/JNEUROSCI.22-17-07730.2002. J Neurosci. 2002. PMID: 12196596 Free PMC article.
The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets.
Tattersall FD, Rycroft W, Cumberbatch M, Mason G, Tye S, Williamson DJ, Hale JJ, Mills SG, Finke PE, MacCoss M, Sadowski S, Ber E, Cascieri M, Hill RG, MacIntyre DE, Hargreaves RJ. Tattersall FD, et al. Neuropharmacology. 2000 Feb 14;39(4):652-63. doi: 10.1016/s0028-3908(99)00172-0. Neuropharmacology. 2000. PMID: 10728886
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