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Alzheimer's disease drug-development pipeline: few candidates, frequent failures.
Cummings JL, Morstorf T, Zhong K. Cummings JL, et al. Alzheimers Res Ther. 2014 Jul 3;6(4):37. doi: 10.1186/alzrt269. eCollection 2014. Alzheimers Res Ther. 2014. PMID: 25024750 Free PMC article.
A roadmap for the prevention of dementia II: Leon Thal Symposium 2008.
Khachaturian ZS, Snyder PJ, Doody R, Aisen P, Comer M, Dwyer J, Frank RA, Holzapfel A, Khachaturian AS, Korczyn AD, Roses A, Simpkins JW, Schneider LS, Albert MS, Egge R, Deves A, Ferris S, Greenberg BD, Johnson C, Kukull WA, Poirier J, Schenk D, Thies W, Gauthier S, Gilman S, Bernick C, Cummings JL, Fillit H, Grundman M, Kaye J, Mucke L, Reisberg B, Sano M, Pickeral O, Petersen RC, Mohs RC, Carrillo M, Corey-Bloom JP, Foster NL, Jacobsen S, Lee V, Potter WZ, Sabbagh MN, Salmon D, Trojanowski JQ, Wexler N, Bain LJ. Khachaturian ZS, et al. Among authors: cummings jl. Alzheimers Dement. 2009 Mar;5(2):85-92. doi: 10.1016/j.jalz.2009.01.021. Alzheimers Dement. 2009. PMID: 19328434 Free PMC article.
Biomarkers in Alzheimer's disease drug development.
Cummings JL. Cummings JL. Alzheimers Dement. 2011 May;7(3):e13-44. doi: 10.1016/j.jalz.2010.06.004. Epub 2011 May 6. Alzheimers Dement. 2011. PMID: 21550318 Review.
Alzheimer's disease clinical trials: changing the paradigm.
Cummings JL. Cummings JL. Curr Psychiatry Rep. 2011 Dec;13(6):437-42. doi: 10.1007/s11920-011-0234-y. Curr Psychiatry Rep. 2011. PMID: 22052382 No abstract available.
Animal systems in the development of treatments for Alzheimer's disease: challenges, methods, and implications.
Sabbagh JJ, Kinney JW, Cummings JL. Sabbagh JJ, et al. Among authors: cummings jl. Neurobiol Aging. 2013 Jan;34(1):169-83. doi: 10.1016/j.neurobiolaging.2012.02.027. Epub 2012 Apr 1. Neurobiol Aging. 2013. PMID: 22464953 Review.
A review: treatment of Alzheimer's disease discovered in repurposed agents.
Appleby BS, Nacopoulos D, Milano N, Zhong K, Cummings JL. Appleby BS, et al. Among authors: cummings jl. Dement Geriatr Cogn Disord. 2013;35(1-2):1-22. doi: 10.1159/000345791. Epub 2013 Jan 9. Dement Geriatr Cogn Disord. 2013. PMID: 23307039 Review.
High-dose donepezil (23 mg/day) for the treatment of moderate and severe Alzheimer's disease: drug profile and clinical guidelines.
Cummings JL, Geldmacher D, Farlow M, Sabbagh M, Christensen D, Betz P. Cummings JL, et al. CNS Neurosci Ther. 2013 May;19(5):294-301. doi: 10.1111/cns.12076. Epub 2013 Mar 6. CNS Neurosci Ther. 2013. PMID: 23462265 Free PMC article. Review.
Alzheimer's disease drug development: translational neuroscience strategies.
Cummings JL, Banks SJ, Gary RK, Kinney JW, Lombardo JM, Walsh RR, Zhong K. Cummings JL, et al. CNS Spectr. 2013 Jun;18(3):128-38. doi: 10.1017/S1092852913000023. Epub 2013 Mar 11. CNS Spectr. 2013. PMID: 23472637 Review.
Alzheimer's disease biomarkers: correspondence between human studies and animal models.
Sabbagh JJ, Kinney JW, Cummings JL. Sabbagh JJ, et al. Among authors: cummings jl. Neurobiol Dis. 2013 Aug;56:116-30. doi: 10.1016/j.nbd.2013.04.010. Epub 2013 Apr 28. Neurobiol Dis. 2013. PMID: 23631871 Review.
International Work Group criteria for the diagnosis of Alzheimer disease.
Cummings JL, Dubois B, Molinuevo JL, Scheltens P. Cummings JL, et al. Med Clin North Am. 2013 May;97(3):363-8. doi: 10.1016/j.mcna.2013.01.001. Epub 2013 Feb 16. Med Clin North Am. 2013. PMID: 23642575
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