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Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein.
Cummins CL, Wu CY, Benet LZ. Cummins CL, et al. Clin Pharmacol Ther. 2002 Nov;72(5):474-89. doi: 10.1067/mcp.2002.128388. Clin Pharmacol Ther. 2002. PMID: 12426511 Review. No abstract available.
1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo.
Chow EC, Durk MR, Cummins CL, Pang KS. Chow EC, et al. Among authors: cummins cl. J Pharmacol Exp Ther. 2011 Jun;337(3):846-59. doi: 10.1124/jpet.111.179101. Epub 2011 Mar 18. J Pharmacol Exp Ther. 2011. PMID: 21421739
Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.
Benet LZ, Cummins CL, Wu CY. Benet LZ, et al. Among authors: cummins cl. Int J Pharm. 2004 Jun 11;277(1-2):3-9. doi: 10.1016/j.ijpharm.2002.12.002. Int J Pharm. 2004. PMID: 15158963 Review.
Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data.
Benet LZ, Cummins CL, Wu CY. Benet LZ, et al. Among authors: cummins cl. Curr Drug Metab. 2003 Oct;4(5):393-8. doi: 10.2174/1389200033489389. Curr Drug Metab. 2003. PMID: 14529371 Review.
The drug efflux-metabolism alliance: biochemical aspects.
Benet LZ, Cummins CL. Benet LZ, et al. Among authors: cummins cl. Adv Drug Deliv Rev. 2001 Oct 1;50 Suppl 1:S3-11. doi: 10.1016/s0169-409x(01)00178-8. Adv Drug Deliv Rev. 2001. PMID: 11576692 Review.
Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.
Cummins CL, Mangravite LM, Benet LZ. Cummins CL, et al. Pharm Res. 2001 Aug;18(8):1102-9. doi: 10.1023/a:1010914624111. Pharm Res. 2001. PMID: 11587480
CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.
Cummins CL, Jacobsen W, Christians U, Benet LZ. Cummins CL, et al. J Pharmacol Exp Ther. 2004 Jan;308(1):143-55. doi: 10.1124/jpet.103.058065. Epub 2003 Oct 20. J Pharmacol Exp Ther. 2004. PMID: 14569063
In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model.
Cummins CL, Salphati L, Reid MJ, Benet LZ. Cummins CL, et al. J Pharmacol Exp Ther. 2003 Apr;305(1):306-14. doi: 10.1124/jpet.102.044719. J Pharmacol Exp Ther. 2003. PMID: 12649383
Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2).
Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ. Flanagan SD, et al. Among authors: cummins cl. Pharmacology. 2002;64(3):126-34. doi: 10.1159/000056161. Pharmacology. 2002. PMID: 11834888
Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.
Cummins CL, Jacobsen W, Benet LZ. Cummins CL, et al. J Pharmacol Exp Ther. 2002 Mar;300(3):1036-45. doi: 10.1124/jpet.300.3.1036. J Pharmacol Exp Ther. 2002. PMID: 11861813
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