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In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.
Houten SM, Volle DH, Cummins CL, Mangelsdorf DJ, Auwerx J. Houten SM, et al. Among authors: cummins cl. Mol Endocrinol. 2007 Jun;21(6):1312-23. doi: 10.1210/me.2007-0113. Epub 2007 Apr 10. Mol Endocrinol. 2007. PMID: 17426284
Minireview: new molecular mediators of glucocorticoid receptor activity in metabolic tissues.
Patel R, Williams-Dautovich J, Cummins CL. Patel R, et al. Among authors: cummins cl. Mol Endocrinol. 2014 Jul;28(7):999-1011. doi: 10.1210/me.2014-1062. Epub 2014 Apr 25. Mol Endocrinol. 2014. PMID: 24766141 Free PMC article. Review.
Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.
Patel R, Bookout AL, Magomedova L, Owen BM, Consiglio GP, Shimizu M, Zhang Y, Mangelsdorf DJ, Kliewer SA, Cummins CL. Patel R, et al. Among authors: cummins cl. Mol Endocrinol. 2015 Feb;29(2):213-23. doi: 10.1210/me.2014-1259. Epub 2014 Dec 11. Mol Endocrinol. 2015. PMID: 25495872 Free PMC article.
1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo.
Chow EC, Durk MR, Cummins CL, Pang KS. Chow EC, et al. Among authors: cummins cl. J Pharmacol Exp Ther. 2011 Jun;337(3):846-59. doi: 10.1124/jpet.111.179101. Epub 2011 Mar 18. J Pharmacol Exp Ther. 2011. PMID: 21421739
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.
Volle DH, Repa JJ, Mazur A, Cummins CL, Val P, Henry-Berger J, Caira F, Veyssiere G, Mangelsdorf DJ, Lobaccaro JM. Volle DH, et al. Among authors: cummins cl. Mol Endocrinol. 2004 Apr;18(4):888-98. doi: 10.1210/me.2003-0338. Epub 2004 Jan 22. Mol Endocrinol. 2004. PMID: 14739254
The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice.
Volle DH, Duggavathi R, Magnier BC, Houten SM, Cummins CL, Lobaccaro JM, Verhoeven G, Schoonjans K, Auwerx J. Volle DH, et al. Among authors: cummins cl. Genes Dev. 2007 Feb 1;21(3):303-15. doi: 10.1101/gad.409307. Genes Dev. 2007. PMID: 17289919 Free PMC article.
Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids.
Katona BW, Cummins CL, Ferguson AD, Li T, Schmidt DR, Mangelsdorf DJ, Covey DF. Katona BW, et al. Among authors: cummins cl. J Med Chem. 2007 Nov 29;50(24):6048-58. doi: 10.1021/jm0707931. Epub 2007 Oct 27. J Med Chem. 2007. PMID: 17963371
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
Lee YK, Schmidt DR, Cummins CL, Choi M, Peng L, Zhang Y, Goodwin B, Hammer RE, Mangelsdorf DJ, Kliewer SA. Lee YK, et al. Among authors: cummins cl. Mol Endocrinol. 2008 Jun;22(6):1345-56. doi: 10.1210/me.2007-0565. Epub 2008 Mar 6. Mol Endocrinol. 2008. PMID: 18323469 Free PMC article.
Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.
Sharma KK, Wang Z, Motola DL, Cummins CL, Mangelsdorf DJ, Auchus RJ. Sharma KK, et al. Among authors: cummins cl. Mol Endocrinol. 2009 May;23(5):640-8. doi: 10.1210/me.2008-0415. Epub 2009 Feb 5. Mol Endocrinol. 2009. PMID: 19196833 Free PMC article.
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.
Gerisch B, Rottiers V, Li D, Motola DL, Cummins CL, Lehrach H, Mangelsdorf DJ, Antebi A. Gerisch B, et al. Among authors: cummins cl. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5014-9. doi: 10.1073/pnas.0700847104. Epub 2007 Mar 14. Proc Natl Acad Sci U S A. 2007. PMID: 17360327 Free PMC article.
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