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Liver X Receptors as Therapeutic Targets for Managing Cholesterol: Implications for Atherosclerosis and Other Inflammatory Conditions.
Zhang Y, Chan JF, Cummins CL. Zhang Y, et al. Among authors: cummins cl. Clin Lipidol. 2009 Feb;4(1):29-40. doi: 10.2217/17584299.4.1.29. Clin Lipidol. 2009. PMID: 20852746 Free PMC article.
Liver X receptors regulate adrenal cholesterol balance.
Cummins CL, Volle DH, Zhang Y, McDonald JG, Sion B, Lefrançois-Martinez AM, Caira F, Veyssière G, Mangelsdorf DJ, Lobaccaro JM. Cummins CL, et al. J Clin Invest. 2006 Jul;116(7):1902-12. doi: 10.1172/JCI28400. J Clin Invest. 2006. PMID: 16823488 Free PMC article.
LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.
Patel R, Patel M, Tsai R, Lin V, Bookout AL, Zhang Y, Magomedova L, Li T, Chan JF, Budd C, Mangelsdorf DJ, Cummins CL. Patel R, et al. Among authors: cummins cl. J Clin Invest. 2011 Jan;121(1):431-41. doi: 10.1172/JCI41681. Epub 2010 Dec 1. J Clin Invest. 2011. PMID: 21123945 Free PMC article.
AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids.
Schmidt DR, Schmidt S, Holmstrom SR, Makishima M, Yu RT, Cummins CL, Mangelsdorf DJ, Kliewer SA. Schmidt DR, et al. Among authors: cummins cl. J Biol Chem. 2011 Jan 28;286(4):2425-32. doi: 10.1074/jbc.M110.181230. Epub 2010 Nov 16. J Biol Chem. 2011. PMID: 21081494 Free PMC article.
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
Umetani M, Domoto H, Gormley AK, Yuhanna IS, Cummins CL, Javitt NB, Korach KS, Shaul PW, Mangelsdorf DJ. Umetani M, et al. Among authors: cummins cl. Nat Med. 2007 Oct;13(10):1185-92. doi: 10.1038/nm1641. Epub 2007 Sep 16. Nat Med. 2007. PMID: 17873880
Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland.
Cummins CL, Mangelsdorf DJ. Cummins CL, et al. Biochem Soc Trans. 2006 Dec;34(Pt 6):1110-3. doi: 10.1042/BST0341110. Biochem Soc Trans. 2006. PMID: 17073762 Review.
The CRH-Transgenic Cushingoid Mouse Is a Model of Glucocorticoid-Induced Osteoporosis.
Williams-Dautovich J, Yogendirarajah K, Dela Cruz A, Patel R, Tsai R, Morgan SA, Mitchell J, Grynpas MD, Cummins CL. Williams-Dautovich J, et al. Among authors: cummins cl. JBMR Plus. 2017 Jun 28;1(1):46-57. doi: 10.1002/jbm4.10009. eCollection 2017 Aug. JBMR Plus. 2017. PMID: 30283880 Free PMC article.
ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development.
Magomedova L, Tiefenbach J, Zilberman E, Le Billan F, Voisin V, Saikali M, Boivin V, Robitaille M, Gueroussov S, Irimia M, Ray D, Patel R, Xu C, Jeyasuria P, Bader GD, Hughes TR, Morris QD, Scott MS, Krause H, Angers S, Blencowe BJ, Cummins CL. Magomedova L, et al. Among authors: cummins cl. Nucleic Acids Res. 2019 Apr 8;47(6):2856-2870. doi: 10.1093/nar/gkz010. Nucleic Acids Res. 2019. PMID: 30698747 Free PMC article.
Minireview: new molecular mediators of glucocorticoid receptor activity in metabolic tissues.
Patel R, Williams-Dautovich J, Cummins CL. Patel R, et al. Among authors: cummins cl. Mol Endocrinol. 2014 Jul;28(7):999-1011. doi: 10.1210/me.2014-1062. Epub 2014 Apr 25. Mol Endocrinol. 2014. PMID: 24766141 Free PMC article. Review.
Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis.
Bashiri A, Nesan D, Tavallaee G, Sue-Chue-Lam I, Chien K, Maguire GF, Naples M, Zhang J, Magomedova L, Adeli K, Cummins CL, Ng DS. Bashiri A, et al. Among authors: cummins cl. Biochim Biophys Acta. 2016 Jul;1861(7):594-605. doi: 10.1016/j.bbalip.2016.04.005. Epub 2016 Apr 14. Biochim Biophys Acta. 2016. PMID: 27090939
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