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Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism.
Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Gottschalk S, et al. Among authors: cummins cl. Neurotoxicology. 2011 Jan;32(1):50-7. doi: 10.1016/j.neuro.2010.10.006. Epub 2010 Nov 12. Neurotoxicology. 2011. PMID: 21075140
CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.
Cummins CL, Jacobsen W, Christians U, Benet LZ. Cummins CL, et al. J Pharmacol Exp Ther. 2004 Jan;308(1):143-55. doi: 10.1124/jpet.103.058065. Epub 2003 Oct 20. J Pharmacol Exp Ther. 2004. PMID: 14569063
1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo.
Chow EC, Durk MR, Cummins CL, Pang KS. Chow EC, et al. Among authors: cummins cl. J Pharmacol Exp Ther. 2011 Jun;337(3):846-59. doi: 10.1124/jpet.111.179101. Epub 2011 Mar 18. J Pharmacol Exp Ther. 2011. PMID: 21421739
Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.
Benet LZ, Cummins CL, Wu CY. Benet LZ, et al. Among authors: cummins cl. Int J Pharm. 2004 Jun 11;277(1-2):3-9. doi: 10.1016/j.ijpharm.2002.12.002. Int J Pharm. 2004. PMID: 15158963 Review.
Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data.
Benet LZ, Cummins CL, Wu CY. Benet LZ, et al. Among authors: cummins cl. Curr Drug Metab. 2003 Oct;4(5):393-8. doi: 10.2174/1389200033489389. Curr Drug Metab. 2003. PMID: 14529371 Review.
The drug efflux-metabolism alliance: biochemical aspects.
Benet LZ, Cummins CL. Benet LZ, et al. Among authors: cummins cl. Adv Drug Deliv Rev. 2001 Oct 1;50 Suppl 1:S3-11. doi: 10.1016/s0169-409x(01)00178-8. Adv Drug Deliv Rev. 2001. PMID: 11576692 Review.
Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.
Cummins CL, Mangravite LM, Benet LZ. Cummins CL, et al. Pharm Res. 2001 Aug;18(8):1102-9. doi: 10.1023/a:1010914624111. Pharm Res. 2001. PMID: 11587480
Strategies and limitations associated with in vitro characterization of vitamin D receptor activators.
Bukuroshi P, Saitoh H, Magomedova L, Cummins CL, Chow EC, Li AP, Pang KS. Bukuroshi P, et al. Among authors: cummins cl. Biochem Pharmacol. 2018 Sep;155:547-561. doi: 10.1016/j.bcp.2018.07.015. Epub 2018 Jul 18. Biochem Pharmacol. 2018. PMID: 30028992
Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.
Patel R, Bookout AL, Magomedova L, Owen BM, Consiglio GP, Shimizu M, Zhang Y, Mangelsdorf DJ, Kliewer SA, Cummins CL. Patel R, et al. Among authors: cummins cl. Mol Endocrinol. 2015 Feb;29(2):213-23. doi: 10.1210/me.2014-1259. Epub 2014 Dec 11. Mol Endocrinol. 2015. PMID: 25495872 Free PMC article.
Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice.
Patel M, Wang XX, Magomedova L, John R, Rasheed A, Santamaria H, Wang W, Tsai R, Qiu L, Orellana A, Advani A, Levi M, Cummins CL. Patel M, et al. Among authors: cummins cl. Diabetologia. 2014 Feb;57(2):435-46. doi: 10.1007/s00125-013-3095-6. Epub 2013 Nov 8. Diabetologia. 2014. PMID: 24201575
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