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Minireview: new molecular mediators of glucocorticoid receptor activity in metabolic tissues.
Patel R, Williams-Dautovich J, Cummins CL. Patel R, et al. Among authors: cummins cl. Mol Endocrinol. 2014 Jul;28(7):999-1011. doi: 10.1210/me.2014-1062. Epub 2014 Apr 25. Mol Endocrinol. 2014. PMID: 24766141 Free PMC article. Review.
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.
Volle DH, Repa JJ, Mazur A, Cummins CL, Val P, Henry-Berger J, Caira F, Veyssiere G, Mangelsdorf DJ, Lobaccaro JM. Volle DH, et al. Among authors: cummins cl. Mol Endocrinol. 2004 Apr;18(4):888-98. doi: 10.1210/me.2003-0338. Epub 2004 Jan 22. Mol Endocrinol. 2004. PMID: 14739254
In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.
Houten SM, Volle DH, Cummins CL, Mangelsdorf DJ, Auwerx J. Houten SM, et al. Among authors: cummins cl. Mol Endocrinol. 2007 Jun;21(6):1312-23. doi: 10.1210/me.2007-0113. Epub 2007 Apr 10. Mol Endocrinol. 2007. PMID: 17426284
Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.
Sharma KK, Wang Z, Motola DL, Cummins CL, Mangelsdorf DJ, Auchus RJ. Sharma KK, et al. Among authors: cummins cl. Mol Endocrinol. 2009 May;23(5):640-8. doi: 10.1210/me.2008-0415. Epub 2009 Feb 5. Mol Endocrinol. 2009. PMID: 19196833 Free PMC article.
LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.
Patel R, Patel M, Tsai R, Lin V, Bookout AL, Zhang Y, Magomedova L, Li T, Chan JF, Budd C, Mangelsdorf DJ, Cummins CL. Patel R, et al. Among authors: cummins cl. J Clin Invest. 2011 Jan;121(1):431-41. doi: 10.1172/JCI41681. Epub 2010 Dec 1. J Clin Invest. 2011. PMID: 21123945 Free PMC article.
1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo.
Chow EC, Durk MR, Cummins CL, Pang KS. Chow EC, et al. Among authors: cummins cl. J Pharmacol Exp Ther. 2011 Jun;337(3):846-59. doi: 10.1124/jpet.111.179101. Epub 2011 Mar 18. J Pharmacol Exp Ther. 2011. PMID: 21421739
Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells.
Chan GN, Hoque MT, Cummins CL, Bendayan R. Chan GN, et al. Among authors: cummins cl. J Neurochem. 2011 Jul;118(2):163-75. doi: 10.1111/j.1471-4159.2011.07288.x. Epub 2011 May 25. J Neurochem. 2011. PMID: 21517853
Induction of P-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells.
Chan GN, Patel R, Cummins CL, Bendayan R. Chan GN, et al. Among authors: cummins cl. Antimicrob Agents Chemother. 2013 Sep;57(9):4481-8. doi: 10.1128/AAC.00486-13. Epub 2013 Jul 8. Antimicrob Agents Chemother. 2013. PMID: 23836171 Free PMC article.
Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice.
Patel M, Wang XX, Magomedova L, John R, Rasheed A, Santamaria H, Wang W, Tsai R, Qiu L, Orellana A, Advani A, Levi M, Cummins CL. Patel M, et al. Among authors: cummins cl. Diabetologia. 2014 Feb;57(2):435-46. doi: 10.1007/s00125-013-3095-6. Epub 2013 Nov 8. Diabetologia. 2014. PMID: 24201575
Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.
Patel R, Bookout AL, Magomedova L, Owen BM, Consiglio GP, Shimizu M, Zhang Y, Mangelsdorf DJ, Kliewer SA, Cummins CL. Patel R, et al. Among authors: cummins cl. Mol Endocrinol. 2015 Feb;29(2):213-23. doi: 10.1210/me.2014-1259. Epub 2014 Dec 11. Mol Endocrinol. 2015. PMID: 25495872 Free PMC article.
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