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Cumulative childhood stress and autoimmune diseases in adults.
Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, Croft JB. Dube SR, et al. Psychosom Med. 2009 Feb;71(2):243-50. doi: 10.1097/PSY.0b013e3181907888. Epub 2009 Feb 2. Psychosom Med. 2009. PMID: 19188532 Free PMC article.
OBJECTIVE: To examine whether childhood traumatic stress increased the risk of developing autoimmune diseases as an adult. ...The total number of ACEs (ACE Score range = 0-8) was used as a measure of cumulative childhood stress …
OBJECTIVE: To examine whether childhood traumatic stress increased the risk of developing autoimmune diseases as …
Defining Early Life Stress as a Precursor for Autoimmune Disease.
Choe JY, Nair M, Basha R, Kim BJ, Jones HP. Choe JY, et al. Crit Rev Immunol. 2019;39(5):329-342. doi: 10.1615/CritRevImmunol.2020033244. Crit Rev Immunol. 2019. PMID: 32422015 Free PMC article. Review.
Recent epidemiological studies have reported higher stress levels in industrialized countries and trends of increasing prevalence in autoimmune diseases during recent decades. To elucidate mechanisms of stress-related immune dysregulation, most animal …
Recent epidemiological studies have reported higher stress levels in industrialized countries and trends of increasing prevalence in …
Association between Adverse Childhood Experiences and Multiple Sclerosis in Icelandic Women-A Population-Based Cohort Study.
Gatto NM, Thordardottir EB, Tomasson G, Rúnarsdóttir H, Song H, Jakobsdóttir J, Aspelund T, Valdimarsdóttir UA, Hauksdóttir A. Gatto NM, et al. Brain Sci. 2022 Nov 16;12(11):1559. doi: 10.3390/brainsci12111559. Brain Sci. 2022. PMID: 36421883 Free PMC article.
BACKGROUND: A growing literature, mostly based on selected populations, indicates that traumas may be associated with autoimmune diseases, yet few studies exist on adverse childhood experiences (ACEs) and multiple sclerosis (MS) in the general population. ... …
BACKGROUND: A growing literature, mostly based on selected populations, indicates that traumas may be associated with autoimmune d …
Trajectories of Childhood Adversity and Type 1 Diabetes: A Nationwide Study of One Million Children.
Bengtsson J, Rieckmann A, Carstensen B, Svensson J, Jørgensen ME, Rod NH. Bengtsson J, et al. Diabetes Care. 2021 Mar;44(3):740-747. doi: 10.2337/dc20-1130. Epub 2021 Jan 25. Diabetes Care. 2021. PMID: 33495291
OBJECTIVE: Experiencing adversities in childhood may increase the risk of type 1 diabetes through hyperactivation of the stress response system, but the empirical evidence is conflicting. ...CONCLUSIONS: Childhood adversities were generally not associated wit …
OBJECTIVE: Experiencing adversities in childhood may increase the risk of type 1 diabetes through hyperactivation of the stress …
The Relation of Multiple Sclerosis to Family History, Lifestyle, and Health Factors in Childhood and Adolescence: Findings of a Case-Control Study Nested Within the German National Cohort (NAKO) Study.
Holz A, Obi N, Pischon T, Schulze MB, Ahrens W, Berger K, Bohn B, Brenner H, Emmel C, Fischer B, Greiser KH, Harth V, Holleczek B, Kaaks R, Karch A, Katzke V, Keil T, Krist L, Leitzmann M, Meinke-Franze C, Michels KB, Nimptsch K, Peters A, Riedel O, Schikowski T, Schipf S, Schmidt B, Thierry S, Hellwig K, Riemann-Lorenz K, Heesen C, Becher H. Holz A, et al. Dtsch Arztebl Int. 2025 Jun 27;112(13):348-354. doi: 10.3238/arztebl.m2025.0069. Dtsch Arztebl Int. 2025. PMID: 40392126 Free PMC article.
Beyond the known risk factors, we observed associations between MS and the cumulative number of common childhood infections (odds ratio (OR) 1.14 per additional infection, 95% confidence interval (CI): [1.03; 1.25]), major stressful life events (SLE) (OR 1.25 …
Beyond the known risk factors, we observed associations between MS and the cumulative number of common childhood infections (o …
The association between stressful life events and respiratory infections during the first 4 years of life: The Environmental Determinants of Diabetes in the Young study.
Roth R, Lynch K, Hyöty H, Lönnrot M, Driscoll KA, Bennett Johnson S; TEDDY Study Group. Roth R, et al. Stress Health. 2019 Aug;35(3):289-303. doi: 10.1002/smi.2861. Epub 2019 Apr 4. Stress Health. 2019. PMID: 30768831 Free PMC article.

In both continents (Europe, RR = 1.12, p < 0.001; United States, RR = 1.07, p = 0.006), high child cumulative NLEs (>1 NLE per year since study inception) was significantly associated with an increased rate of child RIEs. This large-scale prospective study confirms o

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In both continents (Europe, RR = 1.12, p < 0.001; United States, RR = 1.07, p = 0.006), high child cumulative NLEs (>1 NLE per

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