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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 1
1968 2
1969 3
1970 2
1971 6
1972 3
1973 10
1974 4
1975 4
1976 2
1977 5
1978 10
1979 6
1980 3
1981 3
1982 6
1983 6
1984 4
1985 2
1986 2
1987 6
1988 3
1989 1
1990 2
1991 1
1992 1
1993 1
1994 1
1995 1
1996 3
1997 1
1998 5
1999 3
2000 4
2001 11
2002 4
2003 4
2004 15
2005 10
2006 17
2007 18
2008 30
2009 33
2010 29
2011 49
2012 56
2013 57
2014 46
2015 77
2016 64
2017 90
2018 95
2019 122
2020 126
2021 132
2022 125
2023 127
2024 41

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1,312 results

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Page 1
5Z-7-Oxozaenol attenuates cuprizone-induced demyelination in mice through microglia polarization regulation.
Chen S, Liu S, Huang Y, Huang S, Zhang W, Xie H, Lu L. Chen S, et al. Brain Behav. 2024 Apr;14(4):e3487. doi: 10.1002/brb3.3487. Brain Behav. 2024. PMID: 38648385 Free PMC article.
METHODS: Eight-week-old male c57bl/6j mice were randomly divided into five groups: (a) the control group, (b) the group treated with cuprizone (CPZ) only, (c) the group treated with 5Z-7-Oxozaenol (OZ) only, and (d) the group treated with both cuprizone and 15 mug/3 …
METHODS: Eight-week-old male c57bl/6j mice were randomly divided into five groups: (a) the control group, (b) the group treated with cupr …
Magnetic resonance metrics for identification of cuprizone-induced demyelination in the mouse model of neurodegeneration: a review.
Friesen E, Hari K, Sheft M, Thiessen JD, Martin M. Friesen E, et al. MAGMA. 2024 Apr 18. doi: 10.1007/s10334-024-01160-z. Online ahead of print. MAGMA. 2024. PMID: 38635150 Review.
Most commonly, small animal models are used, including Experimental Autoimmune Encephalomyelitis (EAE), Theiler's Murine Encephalomyelitis (TMEV), and toxin models including cuprizone (CPZ), lysolecithin, and ethidium bromide (EtBr). A contrast and comparison of these mode …
Most commonly, small animal models are used, including Experimental Autoimmune Encephalomyelitis (EAE), Theiler's Murine Encephalomyelitis ( …
Conversion of Astrocyte Cell Lines to Oligodendrocyte Progenitor Cells Using Small Molecules and Transplantation to Animal Model of Multiple Sclerosis.
Sharifi-Kelishadi M, Zare L, Fathollahi Y, Javan M. Sharifi-Kelishadi M, et al. J Mol Neurosci. 2024 Apr 9;74(2):40. doi: 10.1007/s12031-024-02206-6. J Mol Neurosci. 2024. PMID: 38594388
To test the in vivo differentiation capabilities, induced OPCs were transplanted into demyelinated mice brains treated with cuprizone over 12 weeks. Two distinct lines of astrocytes demonstrated the potential of conversion to OPCs using this small molecule cocktail as veri …
To test the in vivo differentiation capabilities, induced OPCs were transplanted into demyelinated mice brains treated with cuprizone …
Tannic acid coated nanosuspension for oral delivery of chrysin intended for anti-schizophrenic effect in mice.
Salama A, Hamed Salama A, Hasanein Asfour M. Salama A, et al. Int J Pharm. 2024 Apr 3;656:124085. doi: 10.1016/j.ijpharm.2024.124085. Online ahead of print. Int J Pharm. 2024. PMID: 38580073
The developed formulations and free chrysin were assessed regarding their effect on schizophrenia induced in mice by cuprizone (CPZ). Treatment with the developed formulations and free chrysin ameliorated demyelination and behavioral deficit induced by CPZ via elevating MB …
The developed formulations and free chrysin were assessed regarding their effect on schizophrenia induced in mice by cuprizone (CPZ). …
The therapeutic effect of GAS6 in remyelination is dependent upon Tyro3.
Asadian N, Aprico A, Chen M, Yuen D, Johnston APR, Kilpatrick TJ, Binder MD. Asadian N, et al. Glia. 2024 Apr 4. doi: 10.1002/glia.24534. Online ahead of print. Glia. 2024. PMID: 38572807
We also confirmed that the intracerebroventricular provision of GAS6 for 2 weeks to demyelinated wild-type (WT) mice challenged with cuprizone increased the density of myelinated axons in the corpus callosum by over 2-fold compared with vehicle control. ...
We also confirmed that the intracerebroventricular provision of GAS6 for 2 weeks to demyelinated wild-type (WT) mice challenged with cupr …
Chronic demyelination interferes with normal spermatogenesis in cuprizone-intoxicant C57/BL 6 mice: An experimental study.
Dorikhani A, Omidi A, Movahedin M, Halvaei I. Dorikhani A, et al. Int J Reprod Biomed. 2024 Feb 23;22(1):43-54. doi: 10.18502/ijrm.v22i1.15241. eCollection 2024 Jan. Int J Reprod Biomed. 2024. PMID: 38544672 Free PMC article.
MATERIALS AND METHODS: 20 adult C57/BL6 male mice were divided into 2 groups (n = 10/each) as follows: the control group (CONT) received a regular diet for 17 wk; and the experimental group (cuprizone [CPZ]) was fed with 0.2% CPZ for 12 wk and, then CPZ was withdrawn for 5 …
MATERIALS AND METHODS: 20 adult C57/BL6 male mice were divided into 2 groups (n = 10/each) as follows: the control group (CONT) received a r …
HB-EGF and EGF infusion following CNS demyelination mitigates age-related decline in regeneration of oligodendrocytes from neural precursor cells originating in the ventricular-subventricular zone.
Moradi K, Mitew S, Xing YL, Merson TD. Moradi K, et al. bioRxiv [Preprint]. 2024 Feb 28:2024.02.26.582092. doi: 10.1101/2024.02.26.582092. bioRxiv. 2024. PMID: 38529498 Free PMC article. Preprint.
To enable us to map the fate of NPCs in response to demyelination induced at different postnatal ages, Nestin-CreER(T2);Rosa26-LSL-eYFP mice were gavaged with tamoxifen at either 8 weeks, 30 weeks or one year of age before being challenged with cuprizone for a period of si …
To enable us to map the fate of NPCs in response to demyelination induced at different postnatal ages, Nestin-CreER(T2);Rosa26-LSL-eYFP mice …
Neuroprotective effects of rutin against cuprizone-induced multiple sclerosis in mice.
Nicola MA, Attaai AH, Abdel-Raheem MH, Mohammed AF, Abu-Elhassan YF. Nicola MA, et al. Inflammopharmacology. 2024 Apr;32(2):1295-1315. doi: 10.1007/s10787-024-01442-x. Epub 2024 Mar 21. Inflammopharmacology. 2024. PMID: 38512652 Free PMC article.
Demyelination was induced in in male adult C57BL/6 mice by dietary 0.2% (w/w) cuprizone (CPZ) feeding for 6 consecutive weeks. Treated groups received either oral RUT (50 or 100 mg/kg) or DMF (15 mg/kg), along with CPZ feeding, for 6 consecutive weeks. ...
Demyelination was induced in in male adult C57BL/6 mice by dietary 0.2% (w/w) cuprizone (CPZ) feeding for 6 consecutive weeks. Treate …
AMP-activated protein kinase as a mediator of mitochondrial dysfunction of multiple sclerosis in animal models: A systematic review.
Askari H, Rabiei F, Lohrasbi F, Ghadir S, Mehdipour Arbastan A, Ghasemi-Kasman M. Askari H, et al. J Cell Physiol. 2024 Feb 25. doi: 10.1002/jcp.31230. Online ahead of print. J Cell Physiol. 2024. PMID: 38403972 Review.
These studies collectively revealed a complex relationship between AMPK, mitochondrial dysfunction, and MS pathogenesis, with both cuprizone and experimental autoimmune encephalomyelitis models demonstrating associations between AMPK and mitochondrial disorders, including …
These studies collectively revealed a complex relationship between AMPK, mitochondrial dysfunction, and MS pathogenesis, with both cupriz …
Engineered PDGFA-ligand-modified exosomes delivery T3 for demyelinating disease targeted therapy.
Wang LB, Liao BY, Li YJ, Wang ZH, Yu Y, Li X, Zhang QH. Wang LB, et al. Exp Neurol. 2024 May;375:114730. doi: 10.1016/j.expneurol.2024.114730. Epub 2024 Feb 22. Exp Neurol. 2024. PMID: 38401853 Free article.
Furthermore, the targeted exosomes loaded with 3,5, 30-L-triiodothyronine (T3) have a critical myelination ability in CNS development, administrated to the cuprizone animal model treatment. The data shows that the novel drug vector loaded with T3 significantly promotes rem …
Furthermore, the targeted exosomes loaded with 3,5, 30-L-triiodothyronine (T3) have a critical myelination ability in CNS development, admin …
1,312 results