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Page 1
Glucocorticoid Exposure and Infection in Children and Adults With Glomerular Disease: Findings From the Cure Glomerulonephropathy Study.
Glenn DA, Andrews C, Liu Q, Zee J, Mansfield S, Smith A, O'Shaughnessy MM, Bomback A, Gibson K, Greenbaum LA, Falk RJ, Hogan SL, Mottl A, Denburg MR; CureGN Consortium. Glenn DA, et al. Am J Kidney Dis. 2025 Apr;85(4):528-531. doi: 10.1053/j.ajkd.2024.10.008. Epub 2024 Dec 18. Am J Kidney Dis. 2025. PMID: 39706245 No abstract available.
Family History in the Context of CKD.
Zanoni F, Marasa M, Carlassara L, Verbitsky M, Khan A, Wang C, Bundy JD, Canetta PA, Bomback AS, Parsa A, Feldman HI, Gharavi AG, Kiryluk K; CRIC Study Investigators and the CureGN Study. Zanoni F, et al. J Am Soc Nephrol. 2025 Mar 11. doi: 10.1681/ASN.0000000653. Online ahead of print. J Am Soc Nephrol. 2025. PMID: 40067412
METHODS: We carried out an observational study of two prospective CKD cohorts, 2,573 adults and children from the Cure Glomerulopathy Network (CureGN) and 3,939 Chronic Renal Insufficiency Cohort (CRIC) adult participants. Self-reported first-degree family history of CKD, …
METHODS: We carried out an observational study of two prospective CKD cohorts, 2,573 adults and children from the Cure Glomerulopathy Networ …
Comparing adolescent glomerular disease clinical outcomes to the clinical outcomes in childhood, young adult, and adult-onset glomerular disease in the CureGN database.
Garrity K, Putnam N, Kamil ES, Massengill S, Khalid M, Srivastava R, Isaacs J, Salmon E. Garrity K, et al. Pediatr Nephrol. 2024 Dec 27. doi: 10.1007/s00467-024-06566-4. Online ahead of print. Pediatr Nephrol. 2024. PMID: 39729127
METHODS: We designed a retrospective study using the CureGN database to compare individuals with adolescent-onset glomerular disease relative to individuals with older and younger age at onset. ...
METHODS: We designed a retrospective study using the CureGN database to compare individuals with adolescent-onset glomerular disease …
Clinical Relevance of Computational Pathology Analysis of Interplay Between Kidney Microvasculature and Interstitial Microenvironment.
Chen Y, Wang B, Demeke D, Fan F, Berthier C, Mariani L, Lafata K, Holzman L, Hodgin J, Janowczyk A, Barisoni L, Madabhushi A. Chen Y, et al. Clin J Am Soc Nephrol. 2024 Dec 23;20(2):239-55. doi: 10.2215/CJN.0000000597. Online ahead of print. Clin J Am Soc Nephrol. 2024. PMID: 39714939
This study aimed to identify novel digital biomarkers of disease progression and assess the clinical relevance of the interplay between a variety of PTC characteristics and their microenvironment in glomerular diseases. METHODS: A total of 344 NEPTUNE/CureGN participants w …
This study aimed to identify novel digital biomarkers of disease progression and assess the clinical relevance of the interplay between a va …
Increased risk of kidney failure in patients with genetic kidney disorders.
Elliott MD, Vena N, Marasa M, Cocchi E, Bheda S, Bogyo K, Shang N, Zanoni F, Verbitsky M, Wang C, Kolupaeva V, Jin G, Sofer M, Gras Pena R, Canetta PA, Bomback AS, Guay-Woodford LM, Hou J, Gillespie BW, Robinson BM, Klein JB, Rheault MN, Smoyer WE, Greenbaum LA, Holzman LB, Falk RJ, Parsa A, Sanna-Cherchi S, Mariani LH, Kretzler M, Kiryluk K, Gharavi AG; CureGN Consortium. Elliott MD, et al. J Clin Invest. 2024 Sep 3;134(17):e178573. doi: 10.1172/JCI178573. J Clin Invest. 2024. PMID: 39225089 Free PMC article. Clinical Trial.
BACKGROUNDIt is unknown whether the risk of kidney disease progression and failure differs between patients with and without genetic kidney disorders.METHODSThree cohorts were evaluated: the prospective Cure Glomerulonephropathy Network (CureGN) and 2 retrospective cohorts …
BACKGROUNDIt is unknown whether the risk of kidney disease progression and failure differs between patients with and without genetic kidney …
Association of Obesity With Kidney and Cardiac Outcomes Among Patients With Glomerular Disease: Findings From the Cure Glomerulonephropathy Network.
Zeitler EM, Glenn DA, Hu Y, Falk RJ, Hogan SL, Mottl AK; CureGN Investigators. Zeitler EM, et al. Am J Kidney Dis. 2024 Sep;84(3):306-319.e1. doi: 10.1053/j.ajkd.2024.03.020. Epub 2024 May 13. Am J Kidney Dis. 2024. PMID: 38750877
SETTING & PARTICIPANTS: Participants in the Cure Glomerulonephropathy Network (CureGN) who were5 years of age at enrollment. EXPOSURE: Adult body mass index (BMI) groups: 20-24 (healthy) versus 25-34 (overweight/class 1 obesity) versus35 (class 2-3 obesity); and pediat …
SETTING & PARTICIPANTS: Participants in the Cure Glomerulonephropathy Network (CureGN) who were5 years of age at enrollment. EXPO …
Elevated Exposure to Air Pollutants Accelerates Primary Glomerular Disease Progression.
Troost JP, D'Souza J, Buxton M, Kshirsagar AV, Engel LS, O'Lenick CR, Smoyer WE, Klein J, Ju W, Eddy S, Helmuth M, Mariani LH, Kretzler M, Trachtman H. Troost JP, et al. Kidney Int Rep. 2024 May 18;9(8):2527-2536. doi: 10.1016/j.ekir.2024.05.013. eCollection 2024 Aug. Kidney Int Rep. 2024. PMID: 39156153 Free PMC article.
METHODS: Nephrotic Syndrome Study Network (NEPTUNE) and CureGlomerulonephropathy (CureGN) participants with residential census tract data and 2 years of follow-up were included. ...RESULTS: PM(2.5), BC, and sulfate exposures were comparable in NEPTUNE (n = 228) and Cure …
METHODS: Nephrotic Syndrome Study Network (NEPTUNE) and CureGlomerulonephropathy (CureGN) participants with residential census tract …
Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Disease.
de Cos M, Mosoyan G, Chauhan K, Troost JP, Wong JS, Lefferts S, Morgan P, Meliambro K, Egerman M, Ray J, Parker T, Levine D, Seshan S, Bardash Y, Horowitz B, Kent CA, Shaw MM, Perlman A, Moledina DG, Coca SG, Campbell KN. de Cos M, et al. Am J Kidney Dis. 2024 Aug;84(2):205-214.e1. doi: 10.1053/j.ajkd.2024.01.520. Epub 2024 Mar 5. Am J Kidney Dis. 2024. PMID: 38452919 Free article.
SETTING & PARTICIPANTS: 1,010 patients enrolled in the CureGN Cohort with biopsy-proven glomerular disease (focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A nephropathy). ...
SETTING & PARTICIPANTS: 1,010 patients enrolled in the CureGN Cohort with biopsy-proven glomerular disease (focal segmental glome …
Clinical Relevance of Computationally Derived Tubular Features: Spatial Relationships and the Development of Tubulointerstitial Scarring in MCD/FSGS.
Fan F, Liu Q, Zee J, Ozeki T, Demeke D, Yang Y, Farris AB, Wang B, Shah M, Jacobs J, Mariani L, Lafata K, Rubin J, Chen Y, Holzman L, Hodgin JB, Madabhushi A, Barisoni L, Janowczyk A. Fan F, et al. medRxiv [Preprint]. 2024 Jul 21:2024.07.19.24310619. doi: 10.1101/2024.07.19.24310619. medRxiv. 2024. PMID: 39072032 Free PMC article. Preprint.
METHODS: Deep-learning and image-processing-based segmentations were employed in N=254/266 PAS-WSIs from the NEPTUNE/CureGN datasets (135/153 focal segmental glomerulosclerosis and 119/113 minimal change disease) for: cortex, tubular lumen (TL), epithelium (TE), nuclei (TN …
METHODS: Deep-learning and image-processing-based segmentations were employed in N=254/266 PAS-WSIs from the NEPTUNE/CureGN datasets …
Evaluation of Biomarker-Based Glomerular Filtration Rate Estimating Equations in Glomerular Disease.
Mondal A, Kobe C, Mariani LH, Zee J. Mondal A, et al. Glomerular Dis. 2024 May 16;4(1):119-128. doi: 10.1159/000539353. eCollection 2024 Jan-Dec. Glomerular Dis. 2024. PMID: 39015840 Free PMC article.
In this study, we compared the different GFR estimating equations in the Cure Glomerulonephropathy (CureGN) cohort of children and adults with glomerular disease. METHODS: All available cystatin-C measurements from CureGN study participants were matched to same-day …
In this study, we compared the different GFR estimating equations in the Cure Glomerulonephropathy (CureGN) cohort of children and ad …
38 results