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DNA repair dysregulation from cancer driver to therapeutic target.
Curtin NJ. Curtin NJ. Nat Rev Cancer. 2012 Dec;12(12):801-17. doi: 10.1038/nrc3399. Nat Rev Cancer. 2012. PMID: 23175119 Review.
Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors.
Boulton S, Pemberton LC, Porteous JK, Curtin NJ, Griffin RJ, Golding BT, Durkacz BW. Boulton S, et al. Among authors: curtin nj. Br J Cancer. 1995 Oct;72(4):849-56. doi: 10.1038/bjc.1995.423. Br J Cancer. 1995. PMID: 7547230 Free PMC article.
Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP).
Griffin RJ, Pemberton LC, Rhodes D, Bleasdale C, Bowman K, Calvert AH, Curtin NJ, Durkacz BW, Newell DR, Porteous JK, et al. Griffin RJ, et al. Among authors: curtin nj. Anticancer Drug Des. 1995 Sep;10(6):507-14. Anticancer Drug Des. 1995. PMID: 7575991 No abstract available.
The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy.
Griffin RJ, Curtin NJ, Newell DR, Golding BT, Durkacz BW, Calvert AH. Griffin RJ, et al. Among authors: curtin nj. Biochimie. 1995;77(6):408-22. doi: 10.1016/0300-9084(96)88154-5. Biochimie. 1995. PMID: 7578423 Review.
Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines).
Arris CE, Bleasdale C, Calvert AH, Curtin NJ, Dalby C, Golding BT, Griffin RJ, Lunn JM, Major GN, Newell DR. Arris CE, et al. Among authors: curtin nj. Anticancer Drug Des. 1994 Oct;9(5):401-8. Anticancer Drug Des. 1994. PMID: 7945724 No abstract available.
Dipyridamole increases VP16 growth inhibition, accumulation and retention in parental and multidrug-resistant CHO cells.
Turner RN, Curtin NJ. Turner RN, et al. Among authors: curtin nj. Br J Cancer. 1996 Apr;73(7):856-60. doi: 10.1038/bjc.1996.152. Br J Cancer. 1996. PMID: 8611395 Free PMC article.
Selective potentiation of lometrexol growth inhibition by dipyridamole through cell-specific inhibition of hypoxanthine salvage.
Turner RN, Aherne GW, Curtin NJ. Turner RN, et al. Among authors: curtin nj. Br J Cancer. 1997;76(10):1300-7. doi: 10.1038/bjc.1997.552. Br J Cancer. 1997. PMID: 9374375 Free PMC article.
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.
Bowman KJ, White A, Golding BT, Griffin RJ, Curtin NJ. Bowman KJ, et al. Among authors: curtin nj. Br J Cancer. 1998 Nov;78(10):1269-77. doi: 10.1038/bjc.1998.670. Br J Cancer. 1998. PMID: 9823965 Free PMC article.
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Griffin RJ, Srinivasan S, Bowman K, Calvert AH, Curtin NJ, Newell DR, Pemberton LC, Golding BT. Griffin RJ, et al. Among authors: curtin nj. J Med Chem. 1998 Dec 17;41(26):5247-56. doi: 10.1021/jm980273t. J Med Chem. 1998. PMID: 9857092
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