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Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems.
Sakamoto T, Cullen MD, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Sakamoto T, et al. Among authors: cushman m. J Med Chem. 2007 Jul 12;50(14):3314-21. doi: 10.1021/jm070236e. Epub 2007 Jun 19. J Med Chem. 2007. PMID: 17579385 Free PMC article.
Inhibition of tubulin polymerization by select alkenyldiarylmethanes.
Cullen MD, Sarkar T, Hamel E, Hartman TL, Watson KM, Buckheit RW Jr, Pannecouque C, De Clercq E, Cushman M. Cullen MD, et al. Among authors: cushman m. Bioorg Med Chem Lett. 2008 Jan 15;18(2):469-73. doi: 10.1016/j.bmcl.2007.11.114. Epub 2007 Dec 4. Bioorg Med Chem Lett. 2008. PMID: 18083556 Free PMC article.
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors.
Cullen MD, Cheung YF, Houslay MD, Hartman TL, Watson KM, Buckheit RW Jr, Pannecouque C, De Clercq E, Cushman M. Cullen MD, et al. Among authors: cushman m. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1530-3. doi: 10.1016/j.bmcl.2007.12.015. Epub 2007 Dec 14. Bioorg Med Chem Lett. 2008. PMID: 18222088 Free PMC article.
Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Deng BL, Zhao Y, Hartman TL, Watson K, Buckheit RW Jr, Pannecouque C, De Clercq E, Cushman M. Deng BL, et al. Among authors: cushman m. Eur J Med Chem. 2009 Mar;44(3):1210-4. doi: 10.1016/j.ejmech.2008.09.013. Epub 2008 Sep 19. Eur J Med Chem. 2009. PMID: 18952324 Free PMC article.
1,162 results