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The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study.
Cuya T, Gonçalves ADS, da Silva JAV, Ramalho TC, Kuca K, C C França T. Cuya T, et al. J Biomol Struct Dyn. 2018 Oct;36(13):3444-3452. doi: 10.1080/07391102.2017.1389307. Epub 2017 Oct 27. J Biomol Struct Dyn. 2018. PMID: 29019446
The oximes 4-carbamoyl-1-[({2-[(E)-(hydroxyimino) methyl] pyridinium-1-yl} methoxy) methyl] pyridinium (known as HI-6) and 3-carbamoyl-1-[({2-[(E)-(hydroxyimino) methyl] pyridinium-1-yl} methoxy) methyl] pyridinium (known as HS-6) are isomers differing from each oth …
The oximes 4-carbamoyl-1-[({2-[(E)-(hydroxyimino) methyl] pyridinium-1-yl} methoxy) methyl] pyridinium (known as HI-6) and 3-carbamoy …
Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-tabun conjugate: a molecular modeling approach.
Rodrigues de Souza F, Rodrigues Garcia D, Cuya T, Kuca K, de Alencastro RB, França TCC. Rodrigues de Souza F, et al. J Biomol Struct Dyn. 2018 May;36(6):1430-1438. doi: 10.1080/07391102.2017.1324322. Epub 2017 May 18. J Biomol Struct Dyn. 2018. PMID: 28446076
Tabun is one of the most dangerous nerve agents because it has deleterious effects like inhibition of the essential enzymes acetylcholinesterase (AChE) and butyrylcholinesterase. Some oximes such HI6 as 2-PAM are nucleophiles that are capable to reactivate inhibited human …
Tabun is one of the most dangerous nerve agents because it has deleterious effects like inhibition of the essential enzymes acetylcholineste …