Cuyckens F - Search Results

1

Absorption, metabolism, and excretion of oral ¹⁴C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men.

Scheers E, Leclercq L, de Jong J, Bode N, Bockx M, Laenen A, Cuyckens F, Skee D, Murphy J, Sukbuntherng J, Mannens G. Scheers E, et al. Among authors: cuyckens f. Drug Metab Dispos. 2015 Feb;43(2):289-97. doi: 10.1124/dmd.114.060061. Epub 2014 Dec 8. Drug Metab Dispos. 2015. PMID: 25488930 Clinical Trial.

2

Disposition, metabolism, and excretion of [14C]doripenem after a single 500-milligram intravenous infusion in healthy men.

Cirillo I, Mannens G, Janssen C, Vermeir M, Cuyckens F, Desai-Krieger D, Vaccaro N, Kao LM, Devineni D, Redman R, Turner K. Cirillo I, et al. Among authors: cuyckens f. Antimicrob Agents Chemother. 2008 Oct;52(10):3478-83. doi: 10.1128/AAC.00424-08. Epub 2008 Jul 21. Antimicrob Agents Chemother. 2008. PMID: 18644951 Free PMC article. Clinical Trial.

3

Improved liquid chromatography-Online radioactivity detection for metabolite profiling.

Cuyckens F, Koppen V, Kembuegler R, Leclercq L. Cuyckens F, et al. J Chromatogr A. 2008 Oct 31;1209(1-2):128-35. doi: 10.1016/j.chroma.2008.09.002. Epub 2008 Sep 5. J Chromatogr A. 2008. PMID: 18817918

4

IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers.

Leclercq L, Mortishire-Smith RJ, Huisman M, Cuyckens F, Hartshorn MJ, Hill A. Leclercq L, et al. Among authors: cuyckens f. Rapid Commun Mass Spectrom. 2009 Jan;23(1):39-50. doi: 10.1002/rcm.3854. Rapid Commun Mass Spectrom. 2009. PMID: 19051234

5

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration.

Cuyckens F, Hurkmans R, Castro-Perez JM, Leclercq L, Mortishire-Smith RJ. Cuyckens F, et al. Rapid Commun Mass Spectrom. 2009 Jan;23(2):327-32. doi: 10.1002/rcm.3881. Rapid Commun Mass Spectrom. 2009. PMID: 19089853

6

Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects.

Vermeir M, Lachau-Durand S, Mannens G, Cuyckens F, van Hoof B, Raoof A. Vermeir M, et al. Among authors: cuyckens f. Drug Metab Dispos. 2009 Apr;37(4):809-20. doi: 10.1124/dmd.108.024109. Epub 2009 Jan 8. Drug Metab Dispos. 2009. PMID: 19131522

7

Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

Leclercq L, Cuyckens F, Mannens GS, de Vries R, Timmerman P, Evans DC. Leclercq L, et al. Among authors: cuyckens f. Chem Res Toxicol. 2009 Feb;22(2):280-93. doi: 10.1021/tx800432c. Chem Res Toxicol. 2009. PMID: 19183054 Review.

8

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

Vermeir M, Hemeryck A, Cuyckens F, Francesch A, Bockx M, Van Houdt J, Steemans K, Mannens G, Avilés P, De Coster R. Vermeir M, et al. Among authors: cuyckens f. Biochem Pharmacol. 2009 May 15;77(10):1642-54. doi: 10.1016/j.bcp.2009.02.020. Epub 2009 Mar 10. Biochem Pharmacol. 2009. PMID: 19426702

9

Speciation analysis of bromine-containing drug metabolites in feces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution.

Meermann B, Bockx M, Laenen A, Van Looveren C, Cuyckens F, Vanhaecke F. Meermann B, et al. Among authors: cuyckens f. Anal Bioanal Chem. 2012 Jan;402(1):439-48. doi: 10.1007/s00216-011-5339-y. Epub 2011 Aug 30. Anal Bioanal Chem. 2012. PMID: 21877185 Clinical Trial.

10

Use of relative 12C/14C isotope ratios to estimate metabolite concentrations in the absence of authentic standards.

Cuyckens F, Pauwels N, Koppen V, Leclercq L. Cuyckens F, et al. Bioanalysis. 2012 Jan;4(2):143-56. doi: 10.4155/bio.11.302. Bioanalysis. 2012. PMID: 22250797

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