Identification of the Biosynthetic Gene Cluster for Pyracrimycin A, an Antibiotic Produced by Streptomyces sp.
Nielsen JB, Gren T, Mohite OS, Jørgensen TS, Klitgaard AK, Mourched AS, Blin K, Oves-Costales D, Genilloud O, Larsen TO, Tanner D, Weber T, Gotfredsen CH, Charusanti P.
Nielsen JB, et al.
ACS Chem Biol. 2022 Sep 16;17(9):2411-2417. doi: 10.1021/acschembio.2c00480. Epub 2022 Aug 30.
ACS Chem Biol. 2022.
PMID: 36040247
Here, we report the biosynthetic gene cluster for pyracrimycin A, a set of nine genes that includes a core nonribosomal peptide synthase (pymB) that utilizes serine and proline as precursors and a monooxygenase (pymC) that catalyzes Baeyer-Villiger oxidation. ...Bas …
Here, we report the biosynthetic gene cluster for pyracrimycin A, a set of nine genes that includes a core nonribosomal peptid …