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Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions.
Guan J, Li F, Kang D, Anderson T, Pitcher T, Dalrymple-Alford J, Shorten P, Singh-Mallah G. Guan J, et al. Molecules. 2023 Jan 19;28(3):1021. doi: 10.3390/molecules28031021. Molecules. 2023. PMID: 36770687 Free PMC article. Review.
The reversible binding of IGF-1 to IGF binding protein (IGFBP)-3 regulates the amount of bioavailable, functional IGF-1 in circulation. Cyclic glycine-proline (cGP), a metabolite from the binding site of IGF-1, retains its affinity for IGFBP-3 and comp …
The reversible binding of IGF-1 to IGF binding protein (IGFBP)-3 regulates the amount of bioavailable, functional IGF-1 in circulation. C …
Quantitative Monitoring of Cyclic Glycine-Proline in Marine Mangrove-Derived Fungal Metabolites.
Lin J, Qin F, Lin Z, Lin W, You M, Xu L, Hu L, Chen YH. Lin J, et al. J Fungi (Basel). 2024 Nov 10;10(11):779. doi: 10.3390/jof10110779. J Fungi (Basel). 2024. PMID: 39590698 Free PMC article.
This study developed and validated a robust UPLC-MS/MS method for quantifying cyclic glycine-proline (cGP) in mangrove-derived Penicillium and Aspergillus strains. The method demonstrated excellent linearity, precision, and recovery, with detection lim …
This study developed and validated a robust UPLC-MS/MS method for quantifying cyclic glycine-proline (cGP) in ma …
Cyclic glycine-proline normalizes systolic blood pressure in high-fat diet-induced obese male rats.
Li F, Liu K, Gray C, Harris P, Reynolds CM, Vickers MH, Guan J. Li F, et al. Nutr Metab Cardiovasc Dis. 2020 Feb 10;30(2):339-346. doi: 10.1016/j.numecd.2019.09.016. Epub 2019 Sep 25. Nutr Metab Cardiovasc Dis. 2020. PMID: 31753784
BACKGROUND AND AIMS: Insulin-like growth factor (IGF)-1 deficiency is associated with a range of metabolic disorders. Cyclic glycine-proline (cGP) is a natural nutrient and regulates the amount of active IGF-1 in plasma. ...The beneficial effects of …
BACKGROUND AND AIMS: Insulin-like growth factor (IGF)-1 deficiency is associated with a range of metabolic disorders. Cyclic glyci …
Cyclic glycine-proline administration normalizes high-fat diet-induced synaptophysin expression in obese rats.
Li F, Liu K, Wang A, Harris PWR, Vickers MH, Guan J. Li F, et al. Neuropeptides. 2019 Aug;76:101935. doi: 10.1016/j.npep.2019.05.006. Epub 2019 May 22. Neuropeptides. 2019. PMID: 31146894
Childhood metabolic disorders are associated with insulin-like growth factor (IGF)-1 deficiency, which can adversely affect brain development and function. As a neuropeptide, cyclic glycine-proline (cGP) improves IGF-1 function in brain and regulates I …
Childhood metabolic disorders are associated with insulin-like growth factor (IGF)-1 deficiency, which can adversely affect brain developmen …
Cyclic Glycine-Proline Improves Memory and Reduces Amyloid Plaque Load in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease.
Arora T, Sharma SK. Arora T, et al. Int J Alzheimers Dis. 2023 Mar 1;2023:1753791. doi: 10.1155/2023/1753791. eCollection 2023. Int J Alzheimers Dis. 2023. PMID: 36909366 Free PMC article.
APP/PS1 mice develop amyloid plaques and show memory impairment. Cyclic glycine-proline (cGP) is a cyclic dipeptide that is likely produced from a tripeptide, glycine-proline-glutamate, which itself is generated after proteolytic cleavage of insulin-li …
APP/PS1 mice develop amyloid plaques and show memory impairment. Cyclic glycine-proline (cGP) is a cyclic dipept …
Cyclic-glycine-proline accelerates mammary involution by promoting apoptosis and inhibiting IGF-1 function.
Singh-Mallah G, McMahon CD, Guan J, Singh K. Singh-Mallah G, et al. J Cell Physiol. 2017 Dec;232(12):3369-3383. doi: 10.1002/jcp.25782. Epub 2017 Mar 31. J Cell Physiol. 2017. PMID: 28063218
Overexpression of IGF-1 delays involution by inhibiting apoptosis of epithelial cells and preserving the remaining secretory alveoli. Cyclic-glycine-proline (cGP), a metabolite of IGF-1, normalizes IGF-1 function under pathological conditions by regula …
Overexpression of IGF-1 delays involution by inhibiting apoptosis of epithelial cells and preserving the remaining secretory alveoli. Cyc …
Exploring Sources, Biological Functions, and Potential Applications of the Ubiquitous Marine Cyclic Dipeptide: A Concise Review of Cyclic Glycine-Proline.
Hu L, Lin J, Qin F, Xu L, Luo L. Hu L, et al. Mar Drugs. 2024 Jun 12;22(6):271. doi: 10.3390/md22060271. Mar Drugs. 2024. PMID: 38921582 Free PMC article. Review.
Cyclic glycine-proline (cGP), a prevalent marine cyclic dipeptide, possesses a distinct pyrrolidine-2,5-dione scaffold, which contributes to the chemical diversity and broad bioactivities of cGP. ...By elucidating the considerable value of cG …
Cyclic glycine-proline (cGP), a prevalent marine cyclic dipeptide, possesses a distinct pyrrolidine-2,5-dione sc …
Administration of cyclic glycine-proline during infancy improves adult spatial memory, astrocyte plasticity, vascularization and GluR-1 expression in rats.
Singh-Mallah G, Ardalan M, Kang D, Singh K, McMahon CD, Mallard C, Guan J. Singh-Mallah G, et al. Nutr Neurosci. 2022 Dec;25(12):2517-2527. doi: 10.1080/1028415X.2021.1980845. Epub 2021 Sep 27. Nutr Neurosci. 2022. PMID: 34565308
Cyclic glycine-proline (cGP) is a natural nutrient of breast milk and plays a role in regulating the function of insulin-like growth factor-1 (IGF-1). ...Therefore, cGP may have a role in regulating IGF-1 function during brain development....
Cyclic glycine-proline (cGP) is a natural nutrient of breast milk and plays a role in regulating the function of …
Plasma cyclic glycine proline/IGF-1 ratio predicts clinical outcome and recovery in stroke patients.
Fan D, Krishnamurthi R, Harris P, Barber PA, Guan J. Fan D, et al. Ann Clin Transl Neurol. 2019 Feb 27;6(4):669-677. doi: 10.1002/acn3.743. eCollection 2019 Apr. Ann Clin Transl Neurol. 2019. PMID: 31019991 Free PMC article.
This study evaluated plasma concentrations of IGF-1, IGF binding protein (IGFBP)-3 and cyclic-glycine-proline (cGP) and their associations with clinical outcome in stroke patients. ...INTERPRETATION: Low cGP concentrations and cGP/IGF-1 r …
This study evaluated plasma concentrations of IGF-1, IGF binding protein (IGFBP)-3 and cyclic-glycine-proline (cGP …
Maternally Administered Cyclic Glycine-Proline Increases Insulin-Like Growth Factor-1 Bioavailability and Novelty Recognition in Developing Offspring.
Singh-Mallah G, Singh K, McMahon CD, Harris P, Brimble MA, Thorstensen E, Guan J. Singh-Mallah G, et al. Endocrinology. 2016 Aug;157(8):3130-9. doi: 10.1210/en.2016-1189. Epub 2016 Jun 29. Endocrinology. 2016. PMID: 27355491 Free article.
Cyclic glycine-proline (cGP), a metabolite of IGF-1, is an endogenous neuropeptide that improves memory in adult rats. ...Dams were gavaged with either cGP (3 mg/kg) or saline daily from postnatal days 8-22. Concentrations of cGP were mea …
Cyclic glycine-proline (cGP), a metabolite of IGF-1, is an endogenous neuropeptide that improves memory in adult …
20 results