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Cycloimidamicins, Novel natural lead compounds for translation inhibition in Pseudomonas aeruginosa.
Ishizaki Y, Umekita M, Arisaka R, Hatano M, Kimura T, Kubota Y, Shibuya Y, Hayashi C, Sawa R, Igarashi M. Ishizaki Y, et al. J Antibiot (Tokyo). 2023 Dec;76(12):691-698. doi: 10.1038/s41429-023-00656-5. Epub 2023 Sep 27. J Antibiot (Tokyo). 2023. PMID: 37758819
We screened antibiotics using a highly drug-sensitive P. aeruginosa strain and an oligotrophic medium, and successfully isolated novel antibiotics, namely cycloimidamicins (CIMs), from a rare actinomycete strain, Lentzea sp. MM249-143F7. X-ray and nuclear magnetic resonanc …
We screened antibiotics using a highly drug-sensitive P. aeruginosa strain and an oligotrophic medium, and successfully isolated novel antib …
Catalytic Asymmetric Benzoin Condensation for the Synthesis of Natural Products and Their Analogs.
Abe H, Sasaki K, Sakashita C, Watanabe S, Noda H, Watanabe T, Shibasaki M. Abe H, et al. Org Lett. 2025 Dec 19;27(50):13702-13706. doi: 10.1021/acs.orglett.5c04053. Epub 2025 Dec 4. Org Lett. 2025. PMID: 41343388
Catalytic enantioselective benzoin condensation conditions that are potentially useful for the total synthesis of cycloimidamicins and structure-activity relationship studies of these natural products were developed. ...These conditions showed a broad substrate scope and w …
Catalytic enantioselective benzoin condensation conditions that are potentially useful for the total synthesis of cycloimidamicins an …