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An orally active motilin receptor antagonist, MA-2029, inhibits motilin-induced gastrointestinal motility, increase in fundic tone, and diarrhea in conscious dogs without affecting gastric emptying.
Ozaki K, Onoma M, Muramatsu H, Sudo H, Yoshida S, Shiokawa R, Yogo K, Kamei K, Cynshi O, Kuromaru O, Peeters TL, Takanashi H. Ozaki K, et al. Among authors: cynshi o. Eur J Pharmacol. 2009 Aug 1;615(1-3):185-92. doi: 10.1016/j.ejphar.2009.04.059. Epub 2009 May 13. Eur J Pharmacol. 2009. PMID: 19445919
Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits.
Sudo H, Yoshida S, Ozaki K, Muramatsu H, Onoma M, Yogo K, Kamei K, Cynshi O, Kuromaru O, Peeters TL, Takanashi H. Sudo H, et al. Among authors: cynshi o. Eur J Pharmacol. 2008 Mar 10;581(3):296-305. doi: 10.1016/j.ejphar.2007.11.049. Epub 2007 Nov 28. Eur J Pharmacol. 2008. PMID: 18164286
A novel and selective sodium-glucose cotransporter-2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus.
Ikeda S, Takano Y, Cynshi O, Tanaka R, Christ AD, Boerlin V, Beyer U, Beck A, Ciorciaro C, Meyer M, Kadowaki T. Ikeda S, et al. Among authors: cynshi o. Diabetes Obes Metab. 2015 Oct;17(10):984-93. doi: 10.1111/dom.12538. Epub 2015 Aug 20. Diabetes Obes Metab. 2015. PMID: 26179482 Clinical Trial.
Inhibition of lipoprotein lipid oxidation.
Cynshi O, Stocker R. Cynshi O, et al. Handb Exp Pharmacol. 2005;(170):563-90. doi: 10.1007/3-540-27661-0_21. Handb Exp Pharmacol. 2005. PMID: 16596815 Review.
Anti-oxidative profile of lobenzarit disodium (CCA).
Cynshi O, Saitoh M, Cynshi F, Tanemura M, Hata S, Nakano M. Cynshi O, et al. Among authors: cynshi f. Biochem Pharmacol. 1990 Nov 1;40(9):2117-22. doi: 10.1016/0006-2952(90)90243-e. Biochem Pharmacol. 1990. PMID: 2242038
36 results