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Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770.
Gentzsch M, Ren HY, Houck SA, Quinney NL, Cholon DM, Sopha P, Chaudhry IG, Das J, Dokholyan NV, Randell SH, Cyr DM. Gentzsch M, et al. Among authors: cyr dm. Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L550-9. doi: 10.1152/ajplung.00186.2016. Epub 2016 Jul 8. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27402691 Free PMC article.
From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.
Veit G, Avramescu RG, Chiang AN, Houck SA, Cai Z, Peters KW, Hong JS, Pollard HB, Guggino WB, Balch WE, Skach WR, Cutting GR, Frizzell RA, Sheppard DN, Cyr DM, Sorscher EJ, Brodsky JL, Lukacs GL. Veit G, et al. Among authors: cyr dm. Mol Biol Cell. 2016 Feb 1;27(3):424-33. doi: 10.1091/mbc.E14-04-0935. Mol Biol Cell. 2016. PMID: 26823392 Free PMC article.
Arrest of CFTRDeltaF508 folding.
Cyr DM. Cyr DM. Nat Struct Mol Biol. 2005 Jan;12(1):2-3. doi: 10.1038/nsmb0105-2. Nat Struct Mol Biol. 2005. PMID: 15689966 No abstract available.
Mechanisms for regulation of Hsp70 function by Hsp40.
Fan CY, Lee S, Cyr DM. Fan CY, et al. Among authors: cyr dm. Cell Stress Chaperones. 2003 Winter;8(4):309-16. doi: 10.1379/1466-1268(2003)008<0309:mfrohf>2.0.co;2. Cell Stress Chaperones. 2003. PMID: 15115283 Free PMC article. Review.
101 results