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The following terms were not found in PubMed: P450+half-maximum, concentration+herb-drug, interactions+quercetin+thymoquinone
Page 1
Drug interactions between nine antifungal agents and drugs metabolized by human cytochromes P450.
Niwa T, Imagawa Y, Yamazaki H. Niwa T, et al. Curr Drug Metab. 2014;15(7):651-79. doi: 10.2174/1389200215666141125121511. Curr Drug Metab. 2014. PMID: 25429674 Review.
In in vitro interaction studies, itraconazole, ketoconazole, and miconazole were found to have higher inhibitory effects on cytochrome P450 (P450 or CYP) 3A4 and 3A5 activities than the other azoles or echinocandins did. Fluconazole, itraconazole, and voriconazole w …
In in vitro interaction studies, itraconazole, ketoconazole, and miconazole were found to have higher inhibitory effects on cytoch …
Role of cytochrome b5 in catalysis by cytochrome P450 2B4.
Zhang H, Myshkin E, Waskell L. Zhang H, et al. Biochem Biophys Res Commun. 2005 Dec 9;338(1):499-506. doi: 10.1016/j.bbrc.2005.09.022. Epub 2005 Sep 15. Biochem Biophys Res Commun. 2005. PMID: 16182240 Review.
Cytochrome b5 has been shown to stimulate, inhibit or have no effect on catalysis by P450 cytochromes. ...Determination of the stoichiometry of the metabolism of both substrates showed that the amount of product formed is the net result of the simultaneous stimulato …
Cytochrome b5 has been shown to stimulate, inhibit or have no effect on catalysis by P450 cytochromes. ...Determination of the …
Cytochromes P450 in fungi.
Vanden Bossche H, Koymans L. Vanden Bossche H, et al. Mycoses. 1998;41 Suppl 1:32-8. doi: 10.1111/j.1439-0507.1998.tb00581.x. Mycoses. 1998. PMID: 9717384 Review.
The article gives an overview on the history of the discovery of P450 cytochromes and on their occurrence in nature, especially on their interactions with metabolic pathways in fungi. The significance of the P450 cytochromes in the ergosterol synthesis as well as in …
The article gives an overview on the history of the discovery of P450 cytochromes and on their occurrence in nature, especially on th …
The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b(5).
Im SC, Waskell L. Im SC, et al. Arch Biochem Biophys. 2011 Mar 1;507(1):144-53. doi: 10.1016/j.abb.2010.10.023. Epub 2010 Nov 3. Arch Biochem Biophys. 2011. PMID: 21055385 Free PMC article. Review.
Cytochrome P450 2B4 is a microsomal protein with a multi-step reaction cycle similar to that observed in the majority of other cytochromes P450. ...When the stimulatory and inhibitory effects of cytochrome b(5) are equal, it will appear to have no effe …
Cytochrome P450 2B4 is a microsomal protein with a multi-step reaction cycle similar to that observed in the majority of other cyt …
Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions.
Tang W, Stearns RA. Tang W, et al. Curr Drug Metab. 2001 Jun;2(2):185-98. doi: 10.2174/1389200013338658. Curr Drug Metab. 2001. PMID: 11469725 Review.
Cytochromes P450 (CYP) 3A4 is the most abundant human hepatic CYP isoform catalyzing the metabolism of approximately 50% of therapeutic agents. ...These data imply that CYP cooperativity has the potential to cause in vivo drug-drug interactions. Because cooperative and …
Cytochromes P450 (CYP) 3A4 is the most abundant human hepatic CYP isoform catalyzing the metabolism of approximately 50% of therapeut …
Assessment of drug-drug interaction for silymarin.
Doehmer J, Tewes B, Klein KU, Gritzko K, Muschick H, Mengs U. Doehmer J, et al. Toxicol In Vitro. 2008 Apr;22(3):610-7. doi: 10.1016/j.tiv.2007.11.020. Epub 2007 Dec 8. Toxicol In Vitro. 2008. PMID: 18249085
Silymarin was assessed for drug-drug interaction by permeability studies with Caco-2 cells, for cytochrome P450 induction with human primary hepatocytes and for cytochrome P450 inhibition with human liver microsomes. ...The inhibitory effect was tested on the …
Silymarin was assessed for drug-drug interaction by permeability studies with Caco-2 cells, for cytochrome P450 induction with human …
Recombinant yeast in drug metabolism.
Renaud JP, Peyronneau MA, Urban P, Truan G, Cullin C, Pompon D, Beaune P, Mansuy D. Renaud JP, et al. Toxicology. 1993 Oct 5;82(1-3):39-52. doi: 10.1016/0300-483x(93)90058-z. Toxicology. 1993. PMID: 8236280 Review.
The use of genomically modified yeast strains coexpressing human cytochrome b5 and/or overexpressing yeast P450-reductase allowed us to optimize these catalytic activities. In particular, this coexpression system was useful in the study of the in vitro formation of a P450 …
The use of genomically modified yeast strains coexpressing human cytochrome b5 and/or overexpressing yeast P450-reductase allowed us …
Pharmacokinetic drug interactions with antimicrobial agents.
Gillum JG, Israel DS, Polk RE. Gillum JG, et al. Clin Pharmacokinet. 1993 Dec;25(6):450-82. doi: 10.2165/00003088-199325060-00005. Clin Pharmacokinet. 1993. PMID: 8119047 Review.
Azoles appear to be broad spectrum inhibitors of cytochromes P450. Within each of these antibiotic classes, there is a rank order of inhibitory potency towards specific cytochrome P450 enzymes. By contrast, rifampicin (rifampin) and rifabutin induce several …
Azoles appear to be broad spectrum inhibitors of cytochromes P450. Within each of these antibiotic classes, there is a rank order of …
In vitro inhibitory effects of ganoderic acid A on human liver cytochrome P450 enzymes.
Xu S, Zhang F, Chen D, Su K, Zhang L, Jiang R. Xu S, et al. Pharm Biol. 2020 Dec;58(1):308-313. doi: 10.1080/13880209.2020.1747500. Pharm Biol. 2020. PMID: 32285742 Free PMC article.
Context: Ganoderic acid A (GAA) is usually used to prevent cancers or other diseases, which make it likely to be used with other drugs metabolized by cytochromes P450.Objective: This study investigates the effect of GAA on eight major cytochrome P450 isoforms in hum …
Context: Ganoderic acid A (GAA) is usually used to prevent cancers or other diseases, which make it likely to be used with other drugs metab …
Analysis of the interactions of cytochrome b5 with flavocytochrome P450 BM3 and its domains.
Noble MA, Girvan HM, Smith SJ, Smith WE, Murataliev M, Guzov VM, Feyereisen R, Munro AW. Noble MA, et al. Drug Metab Rev. 2007;39(2-3):599-617. doi: 10.1080/03602530701468458. Drug Metab Rev. 2007. PMID: 17786641
Interactions between a soluble form of microsomal cytochrome b(5) (b(5)) from Musca domestica (housefly) and Bacillus megaterium flavocytochrome P450 BM3 and its component reductase (CPR), heme (P450) and FAD/NADPH-binding (FAD) domains were analyzed by a combination of st …
Interactions between a soluble form of microsomal cytochrome b(5) (b(5)) from Musca domestica (housefly) and Bacillus megaterium flav …
9,370 results