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Did you mean cytogenic (457 results)?
Biosynthesis of antitumor antibiotic, cytogenin.
Kumagai H, Amemiya M, Naganawa H, Sawa T, Ishizuka M, Takeuchi T. Kumagai H, et al. J Antibiot (Tokyo). 1994 Apr;47(4):440-6. doi: 10.7164/antibiotics.47.440. J Antibiot (Tokyo). 1994. PMID: 8195044 Free article.
The biosynthesis of antitumor antibiotic cytogenin, 3-hydroxymethyl-6-methoxy-8-hydroxy-isocoumarin, was studied by feeding 14C- or 13C-labeled compounds to culture of the producing organism, Streptoverticillium eurocidicum MI43-37F11. 14C-Acetate and 14C-methionine were e …
The biosynthesis of antitumor antibiotic cytogenin, 3-hydroxymethyl-6-methoxy-8-hydroxy-isocoumarin, was studied by feeding 14C- or 1 …
Cytogenin, a novel antitumor substance.
Kumagai H, Masuda T, Ohsono M, Hattori S, Naganawa H, Sawa T, Hamada M, Ishizuka M, Takeuchi T. Kumagai H, et al. J Antibiot (Tokyo). 1990 Nov;43(11):1505-7. doi: 10.7164/antibiotics.43.1505. J Antibiot (Tokyo). 1990. PMID: 2272926 Free article. No abstract available.
Antitumor activity of cytogenin.
Kumagai H, Masuda T, Ishizuka M, Takeuchi T. Kumagai H, et al. J Antibiot (Tokyo). 1995 Feb;48(2):175-8. doi: 10.7164/antibiotics.48.175. J Antibiot (Tokyo). 1995. PMID: 7706130 Free article.
Antitumor effect of cytogenin against IMC carcinoma in mice was investigated. Since cytogenin did not show cytotoxicity against tumor cells in vitro at 50 micrograms/ml and toxicity at more than 2,000 mg/kg i.p., it was considered that the antitumor effect is due to …
Antitumor effect of cytogenin against IMC carcinoma in mice was investigated. Since cytogenin did not show cytotoxicity agains …
Effects of cytogenin, a novel anti-arthritic agent, on type II collagen-induced arthritis in DBA/1J mice and adjuvant arthritis in Lewis rats.
Hirano S, Wakazono K, Agata N, Mase T, Yamamoto R, Matsufuji M, Sakata N, Iguchi H, Tone H, Ishizuka M, et al. Hirano S, et al. Int J Tissue React. 1994;16(4):155-62. Int J Tissue React. 1994. PMID: 7797401
Prophylactic treatment with cytogenin (30, 100 mg/kg) had a potent inhibitory effect on type II collagen-induced arthritis. ...These results suggest that the mode of the anti-arthritic action of cytogenin is different from that of NSAIDs and that cytogenin ma …
Prophylactic treatment with cytogenin (30, 100 mg/kg) had a potent inhibitory effect on type II collagen-induced arthritis. ...These …
Effects of cytogenin, a novel microbial product, on embryonic and tumor cell-induced angiogenic responses in vivo.
Oikawa T, Sasaki M, Inose M, Shimamura M, Kuboki H, Hirano S, Kumagai H, Ishizuka M, Takeuchi T. Oikawa T, et al. Anticancer Res. 1997 May-Jun;17(3C):1881-6. Anticancer Res. 1997. PMID: 9216639
Cytogenin (8-hydroxy-3-hydroxymethyl-6-methoxyisocoumarin) is a new microbial product with antitumor and antirheumatoid arthritis effects in vivo when administered orally, although its mechanism(s) of action is not known well. ...Pharmacokinetic studies in mice revealed th …
Cytogenin (8-hydroxy-3-hydroxymethyl-6-methoxyisocoumarin) is a new microbial product with antitumor and antirheumatoid arthritis eff …
Synthesis and biological evaluation of cytogenin derivatives.
Matsumoto N, Nakashima T, Isshiki K, Kuboki H, Hirano SI, Kumagai H, Yoshioka T, Ishizuka M, Takeuchi T. Matsumoto N, et al. J Antibiot (Tokyo). 2001 Mar;54(3):285-96. doi: 10.7164/antibiotics.54.285. J Antibiot (Tokyo). 2001. PMID: 11372785 Free article.
To enhance the stability in vivo, new derivatives of cytogenin were synthesized, and their biological activity and stability in mice were estimated. 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid (NM-3) was found to be the most stable among them. ...
To enhance the stability in vivo, new derivatives of cytogenin were synthesized, and their biological activity and stability in mice …
Action of cytogenin on lymphoid cells and their cytokine production.
Kumagai H, Osono M, Iijima M, Sakashita M, Ishizuka M, Takeuchi T. Kumagai H, et al. J Antibiot (Tokyo). 1995 Apr;48(4):317-20. doi: 10.7164/antibiotics.48.317. J Antibiot (Tokyo). 1995. PMID: 7775269 Free article.
Action of cytogenin on macrophages and T cells was investigated. Phagocytosis of yeast and production of PMA-elicited superoxide anion by macrophages taken from mice given cytogenin po were augmented. ...Macrophages stimulated with cytogenin caused to stimula …
Action of cytogenin on macrophages and T cells was investigated. Phagocytosis of yeast and production of PMA-elicited superoxide anio …
Effect of cytogenin, a novel immunomodulator, on streptozotocin-induced diabetes in mice.
Kumagai H, Wakazono K, Agata N, Isshiki K, Ishizuka M, Ikeda D. Kumagai H, et al. J Antibiot (Tokyo). 2005 Mar;58(3):202-5. doi: 10.1038/ja.2005.24. J Antibiot (Tokyo). 2005. PMID: 15895529
The anti-diabetic effect of cytogenin was examined using streptozotocin-induced diabetes in mice. Cytogenin suppressed not only the increase of plasma glucose level but also the body weight reduction in diabetic mice. Histological examination of the pancreas taken f …
The anti-diabetic effect of cytogenin was examined using streptozotocin-induced diabetes in mice. Cytogenin suppressed not onl …
Modulation of macrophage activity in tumor bearing mice by cytogenin.
Kumagai H, Masuda T, Sakashita M, Ishizuka M, Takeuchi T. Kumagai H, et al. J Antibiot (Tokyo). 1995 Apr;48(4):321-5. doi: 10.7164/antibiotics.48.321. J Antibiot (Tokyo). 1995. PMID: 7775270 Free article.
Cytogenin recovered the reduced mitogenic response to Con A of spleen cells of tumor bearing mice in vitro. ...The reduced antitumor effector activity of spleen cells taken from tumor bearing mice was also augmented by the treatment with cytogenin in vitro. The effe …
Cytogenin recovered the reduced mitogenic response to Con A of spleen cells of tumor bearing mice in vitro. ...The reduced antitumor …
Effects of cytogenin on spontaneous arthritis in MRL/1 mice and on pristane-induced arthritis (PIA) in DBA/1J mice.
Abe C, Hirano S, Wakazono K, Mase T, Yamamoto R, Matsufuji M, Sakata N, Agata N, Iguchi H, Ishizuka M, et al. Abe C, et al. Int J Tissue React. 1995;17(5-6):175-80. Int J Tissue React. 1995. PMID: 8835627
Cytogenin, 8-hydroxy-3-hydroxymethyl-6-methoxyisocoumarin, has low cytotoxicity on murine and human tumour cells in vitro. ...The results suggest that the mode of the anti-arthritic action of cytogenin is different from those of NSAIDs; although the precise mode of …
Cytogenin, 8-hydroxy-3-hydroxymethyl-6-methoxyisocoumarin, has low cytotoxicity on murine and human tumour cells in vitro. ...The res …
14 results